TY - JOUR
T1 - Mesoporous silica nanoparticles with manganese and lanthanide salts
T2 - synthesis, characterization and cytotoxicity studies
AU - Forte, Andreia
AU - Gago, Sandra
AU - Ribeiro Carrott, Manuela
AU - Carrott, Peter
AU - Alves, Celso
AU - Teodoro, Fernando
AU - Pedrosa, Rui
AU - Marrucho, Isabel M.
AU - Branco, Luis C.
N1 - Funding Information:
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00100%2F2020/PT#
PY - 2021/6/28
Y1 - 2021/6/28
N2 - Several organic salts based on the combination of two different choline derivative cations and MnCl3−, GdCl4−and TbCl4−as anions were immobilized in mesoporous silica nanoparticles (MSNs) by a two-step synthetic method. Firstly, MSNs were functionalized with choline derivative cations with chloride anions and then the metals were incorporated by the reaction of the chloride with the respective metal chloride salts. These nanomaterials were fully characterized by different characterization techniques such as1H-NMR, FT-IR, elemental analysis, TEM, TGA, N2adsorption, XRD and DLS. These characterization data were important to confirm the successful functionalization of the nanomaterials and to access their textural properties and colloidal stability. The final materials were also characterized by ICP-MS that indicated the metal contents. The cytotoxicity profile was evaluated in four different cell lines (3T3, 293T, HepG2 and Caco-2), which shows some relevant differences between the metal organic salts and their immobilized analogues.
AB - Several organic salts based on the combination of two different choline derivative cations and MnCl3−, GdCl4−and TbCl4−as anions were immobilized in mesoporous silica nanoparticles (MSNs) by a two-step synthetic method. Firstly, MSNs were functionalized with choline derivative cations with chloride anions and then the metals were incorporated by the reaction of the chloride with the respective metal chloride salts. These nanomaterials were fully characterized by different characterization techniques such as1H-NMR, FT-IR, elemental analysis, TEM, TGA, N2adsorption, XRD and DLS. These characterization data were important to confirm the successful functionalization of the nanomaterials and to access their textural properties and colloidal stability. The final materials were also characterized by ICP-MS that indicated the metal contents. The cytotoxicity profile was evaluated in four different cell lines (3T3, 293T, HepG2 and Caco-2), which shows some relevant differences between the metal organic salts and their immobilized analogues.
UR - http://www.scopus.com/inward/record.url?scp=85108587455&partnerID=8YFLogxK
U2 - 10.1039/d1dt00605c
DO - 10.1039/d1dt00605c
M3 - Article
C2 - 34075980
AN - SCOPUS:85108587455
VL - 50
SP - 8588
EP - 8599
JO - Dalton transactions (Cambridge, England : 2003)
JF - Dalton transactions (Cambridge, England : 2003)
SN - 1477-9234
IS - 24
ER -