Abstract
Inspired by one of the major problems in the pharmaceutical industry, we advantageously used the formation of eutectic mixtures to synthesize new solvents. The aim of this work is to identify low viscosity, cheap, biodegradable and hydrophobic eutectic solvents from natural resources. Consequently, novel eutectic mixtures based on DL-menthol and naturally occurring acids, namely pyruvic acid, acetic acid, L-lactic acid, and lauric acid, were synthesized and are here reported for the first time. The obtained DLmenthol-based eutectic mixtures were analyzed using NMR and FTIR spectroscopy in order to check their structures and purities and to confirm the interaction of the two compounds leading to the eutectic formation. Important solvent thermophysical properties, such as density and viscosity, of the prepared eutectic solvents with different water contents (dried and watersaturated) were measured. Finally, taking advantage of their hydrophobic character, namely the formation of two phases with water at room temperature, four different biomolecules, caffeine, tryptophan, isophthalic acid, and vanillin, were extracted and the extraction efficiencies of the prepared eutectic solvents compared.
| Original language | English |
|---|---|
| Pages (from-to) | 2469-2477 |
| Number of pages | 9 |
| Journal | ACS SUSTAINABLE CHEMISTRY & ENGINEERING |
| Volume | 3 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 10 Sep 2015 |
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Keywords
- Eutectic mixtures
- Green solvents
- Hydrophobicity
- Menthol
- Thermophysical and aqueous phase equilibria properties
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Menthol-based eutectic mixtures : Hydrophobic low viscosity solvents. / Ribeiro, Bernardo D.; Florindo, Catarina; Iff, Lucas C.; Coelho, Maria A Z; Marrucho Ferreira, Isabel Maria.
In: ACS SUSTAINABLE CHEMISTRY & ENGINEERING, Vol. 3, No. 10, 10.09.2015, p. 2469-2477.Research output: Contribution to journal › Article
TY - JOUR
T1 - Menthol-based eutectic mixtures
T2 - Hydrophobic low viscosity solvents
AU - Ribeiro, Bernardo D.
AU - Florindo, Catarina
AU - Iff, Lucas C.
AU - Coelho, Maria A Z
AU - Marrucho Ferreira, Isabel Maria
PY - 2015/9/10
Y1 - 2015/9/10
N2 - Inspired by one of the major problems in the pharmaceutical industry, we advantageously used the formation of eutectic mixtures to synthesize new solvents. The aim of this work is to identify low viscosity, cheap, biodegradable and hydrophobic eutectic solvents from natural resources. Consequently, novel eutectic mixtures based on DL-menthol and naturally occurring acids, namely pyruvic acid, acetic acid, L-lactic acid, and lauric acid, were synthesized and are here reported for the first time. The obtained DLmenthol-based eutectic mixtures were analyzed using NMR and FTIR spectroscopy in order to check their structures and purities and to confirm the interaction of the two compounds leading to the eutectic formation. Important solvent thermophysical properties, such as density and viscosity, of the prepared eutectic solvents with different water contents (dried and watersaturated) were measured. Finally, taking advantage of their hydrophobic character, namely the formation of two phases with water at room temperature, four different biomolecules, caffeine, tryptophan, isophthalic acid, and vanillin, were extracted and the extraction efficiencies of the prepared eutectic solvents compared.
AB - Inspired by one of the major problems in the pharmaceutical industry, we advantageously used the formation of eutectic mixtures to synthesize new solvents. The aim of this work is to identify low viscosity, cheap, biodegradable and hydrophobic eutectic solvents from natural resources. Consequently, novel eutectic mixtures based on DL-menthol and naturally occurring acids, namely pyruvic acid, acetic acid, L-lactic acid, and lauric acid, were synthesized and are here reported for the first time. The obtained DLmenthol-based eutectic mixtures were analyzed using NMR and FTIR spectroscopy in order to check their structures and purities and to confirm the interaction of the two compounds leading to the eutectic formation. Important solvent thermophysical properties, such as density and viscosity, of the prepared eutectic solvents with different water contents (dried and watersaturated) were measured. Finally, taking advantage of their hydrophobic character, namely the formation of two phases with water at room temperature, four different biomolecules, caffeine, tryptophan, isophthalic acid, and vanillin, were extracted and the extraction efficiencies of the prepared eutectic solvents compared.
KW - Eutectic mixtures
KW - Green solvents
KW - Hydrophobicity
KW - Menthol
KW - Thermophysical and aqueous phase equilibria properties
UR - http://www.scopus.com/inward/record.url?scp=84983664729&partnerID=8YFLogxK
U2 - 10.1021/acssuschemeng.5b00532
DO - 10.1021/acssuschemeng.5b00532
M3 - Article
VL - 3
SP - 2469
EP - 2477
JO - ACS SUSTAINABLE CHEMISTRY & ENGINEERING
JF - ACS SUSTAINABLE CHEMISTRY & ENGINEERING
SN - 2168-0485
IS - 10
ER -