Melanosomes on the move: a model to understand organelle dynamics

Alistair N Hume, Miguel C. Seabra

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Advances in live-cell microscopy have revealed the extraordinarily dynamic nature of intracellular organelles. Moreover, movement appears to be critical in establishing and maintaining intracellular organization and organellar and cellular function. Motility is regulated by the activity of organelle-associated motor proteins, kinesins, dyneins and myosins, which move cargo along polar MT (microtubule) and actin tracks. However, in most instances, the motors that move specific organelles remain mysterious. Over recent years, pigment granules, or melanosomes, within pigment cells have provided an excellent model for understanding the molecular mechanisms by which motor proteins associate with and move intracellular organelles. In the present paper, we discuss recent discoveries that shed light on the mechanisms of melanosome transport and highlight future prospects for the use of pigment cells in unravelling general molecular mechanisms of intracellular transport.
Original languageEnglish
Pages (from-to)1191-1196
Number of pages6
JournalBiochemical Society Transactions
Volume39
Issue numberNA
DOIs
Publication statusPublished - 21 Sep 2011

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