Medicinal Attributes of Lignans Extracted from Piper Cubeba: Current Developments

Regiane Godoy de Lima, Maria Teresa Barros, Rosangela da Silva Laurentiz

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)


Lignans are a large class of natural products that have been isolated from many plants. They reveal diverse biological activities, especially antiviral and antitumor properties. From Piper cubeba, lignans of several classes can be isolated from the roots, rhizomes, stems, leaves, seeds, and fruits. Among its various chemical constituents, (−)-cubebin and (−)-hinokinin are found in significant quantities. Although they have been known for some time, during the last few decades their biological properties have been studied by several research groups. The cubebins have been identified as a lactol monomer and dimers as a mixture of diastereoisomers. Recently, their structural characterization and the synthesis of the possible structures have led to the correction of some earlier structural proposals. This review describes the more recent developments in the study of the medicinal attributes of cubebin and hinokinin extracted from Piper cubeba and the synthesis and biological testing of some analogues.

Original languageEnglish
Pages (from-to)180-191
Number of pages12
Issue number2
Publication statusPublished - 1 Feb 2018


  • biological activity
  • lignans
  • natural products
  • oxygen heterocycles
  • total synthesis


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