TY - JOUR
T1 - Medicinal Attributes of Lignans Extracted from Piper Cubeba: Current Developments
AU - Godoy de Lima, Regiane
AU - Barros, Maria Teresa
AU - da Silva Laurentiz, Rosangela
N1 - info:eu-repo/grantAgreement/FCT/5876/147218/PT#
PSDE/88881.134923/ 2016-01.
POCI-01–0145-FEDER -007265.
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Lignans are a large class of natural products that have been isolated from many plants. They reveal diverse biological activities, especially antiviral and antitumor properties. From Piper cubeba, lignans of several classes can be isolated from the roots, rhizomes, stems, leaves, seeds, and fruits. Among its various chemical constituents, (−)-cubebin and (−)-hinokinin are found in significant quantities. Although they have been known for some time, during the last few decades their biological properties have been studied by several research groups. The cubebins have been identified as a lactol monomer and dimers as a mixture of diastereoisomers. Recently, their structural characterization and the synthesis of the possible structures have led to the correction of some earlier structural proposals. This review describes the more recent developments in the study of the medicinal attributes of cubebin and hinokinin extracted from Piper cubeba and the synthesis and biological testing of some analogues.
AB - Lignans are a large class of natural products that have been isolated from many plants. They reveal diverse biological activities, especially antiviral and antitumor properties. From Piper cubeba, lignans of several classes can be isolated from the roots, rhizomes, stems, leaves, seeds, and fruits. Among its various chemical constituents, (−)-cubebin and (−)-hinokinin are found in significant quantities. Although they have been known for some time, during the last few decades their biological properties have been studied by several research groups. The cubebins have been identified as a lactol monomer and dimers as a mixture of diastereoisomers. Recently, their structural characterization and the synthesis of the possible structures have led to the correction of some earlier structural proposals. This review describes the more recent developments in the study of the medicinal attributes of cubebin and hinokinin extracted from Piper cubeba and the synthesis and biological testing of some analogues.
KW - biological activity
KW - lignans
KW - natural products
KW - oxygen heterocycles
KW - total synthesis
UR - http://www.scopus.com/inward/record.url?scp=85042523747&partnerID=8YFLogxK
U2 - 10.1002/open.201700182
DO - 10.1002/open.201700182
M3 - Review article
C2 - 29435403
AN - SCOPUS:85042523747
VL - 7
SP - 180
EP - 191
JO - ChemistryOpen
JF - ChemistryOpen
SN - 2191-1363
IS - 2
ER -