MechanoAPI-ILs: Pharmaceutical Ionic Liquids Obtained through Mechanochemical Synthesis

Inês C.B. Martins, M. Conceição Oliveira, Hermínio P. Diogo, Luís C. Branco, M. Teresa Duarte

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


An alternative, efficient, and green synthetic strategy for the preparation of pharmaceutical ionic liquids using mechanochemistry (MechanoAPI-ILs) is reported. Six new API-ILs based on gabapentin and l-glutamic acid were successfully synthesized and characterized, demonstrating that mechanochemistry is a very promising synthetic strategy. Results compare both the new and the classical approach and clearly show the advantages of the new method. This new technique is faster, solvent free, reproducible, selective, and leads to higher yields.

Original languageEnglish
Pages (from-to)1360-1363
Number of pages4
Issue number7
Publication statusPublished - 10 Apr 2017


  • gabapentin
  • ionic liquids
  • l-glutamic acid
  • mechanochemistry
  • pharmaceutical


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