Mass spectrometry as a quantitative tool in plant metabolomics

Tiago F. Jorge, Ana M T Mata, Carla António

Research output: Contribution to journalReview articlepeer-review

64 Citations (Scopus)


Metabolomics is a research field used to acquire comprehensive information on the composition of a metabolite pool to provide a functional screen of the cellular state. Studies of the plant metabolome include the analysis of a wide range of chemical species with very diverse physico-chemical properties, and therefore powerful analytical tools are required for the separation, characterization and quantification of this vast compound diversity present in plant matrices. In this review, challenges in the use ofmass spectrometry (MS) as a quantitative tool in plant metabolomics experiments are discussed, and important criteria for the development and validation of MS-based analytical methods provided.

Original languageEnglish
Article number20150370
JournalPhilosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
Issue number2079
Publication statusPublished - 28 Oct 2016


  • Analytical recoveries
  • Mass spectrometry
  • Matrix effects
  • Metabolite quantification
  • Method validation
  • Plant metabolomics


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