Marcadores inflamatorios preoperatorios en el cáncer medular de tiroides

Translated title of the contribution: Preoperative serum inflammation-based scores in medullary thyroid cancer

Ana Abrantes Figueiredo, Susana Esteves, Margarida Maria Moura, Pedro Marques, Joana Simões-Pereira, Valeriano Leite

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Introduction: Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) are prognostic factors in several tumours, though little is known in medullary thyroid cancer (MTC). Objective: To evaluate the association between preoperative NLR, PLR and SII with MTC clinicopathological and molecular features, and their predictive value for lymph node and distant metastasis. Methods: We retrospectively analysed 75 patients with MTC who underwent surgery at our institution. The familial form of MTC was found in 12% of patients. Results: In our cohort, 56% were females, the median age at diagnosis was 57 years (44–69), the median tumour diameter was 25 mm (15–50); 21.3% were multifocal and 34.7% had extrathyroidal extension. Lymph node and distant metastasis were observed in 36 (48.0%) and 8 (10.7%) patients, respectively. Higher NLR was associated with preoperative calcitonin, angioinvasion, extrathyroidal extension, moderate/severe fibrosis; higher PLR was associated with extrathyroidal extension and advanced T stages; lower SII and NLR were associated with biochemical cure after surgery. Increased PLR, NLR and SII were associated with advanced MTC stages. In the univariate analysis, only NLR was associated with lymph node metastasis (odds ratio (OR) = 2.69, 95% confidence interval (CI): 1.50–5.84; p = 0.004); however, in the multivariate model, NLR was no longer a predictive factor for lymph node metastasis. None of these serum inflammatory markers predicted the occurrence of distant metastasis. Conclusion: In conclusion, NLR, PLR and SII are associated with aggressive MTC, but do not predict lymph node or distant metastasis.

Translated title of the contributionPreoperative serum inflammation-based scores in medullary thyroid cancer
Original languageSpanish
Pages (from-to)48 - 55
JournalEndocrinologia, Diabetes y Nutricion
Issue number1
Early online date1 Oct 2022
Publication statusPublished - Jan 2023


  • Medullary thyroid cancer
  • Neutrophil-to-lymphocyte ratio
  • Neutrophil-to-platelet ratio
  • Systemic immune-inflammation index


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