Malaria combination therapies: Advantages and shortcomings

A. Martinelli; R. Moreira; P. V.L. Cravo

doi:10.2174/138955708783744092

Malaria combination therapies: Advantages and shortcomings

A. Martinelli, R. Moreira, P. V.L. Cravo

Research output: Contribution to journal › Review article › peer-review

38 Citations (Scopus)

Abstract

Drug combination therapies have been devised to delay the development and spread of resistant malaria parasites. However, poor design often leads to ineffective combinations. Here, the properties of various drug combinations are reviewed in relationship to drug resistance and their pharmacokinetic compatibility.

Original language	English
Pages (from-to)	201-212
Number of pages	12
Journal	Mini-Reviews in Medicinal Chemistry
Volume	8
Issue number	3
DOIs	https://doi.org/10.2174/138955708783744092
Publication status	Published - 1 Mar 2008

Keywords

Antifolates
Artemisinin
Drug combination therapy
Drug resistance
Malaria
Quinolines

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2174/138955708783744092

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title = "Malaria combination therapies: Advantages and shortcomings",

abstract = "Drug combination therapies have been devised to delay the development and spread of resistant malaria parasites. However, poor design often leads to ineffective combinations. Here, the properties of various drug combinations are reviewed in relationship to drug resistance and their pharmacokinetic compatibility.",

keywords = "Antifolates, Artemisinin, Drug combination therapy, Drug resistance, Malaria, Quinolines",

author = "A. Martinelli and R. Moreira and Cravo, {P. V.L.}",

year = "2008",

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T1 - Malaria combination therapies

T2 - Advantages and shortcomings

AU - Martinelli, A.

AU - Moreira, R.

AU - Cravo, P. V.L.

PY - 2008/3/1

Y1 - 2008/3/1

N2 - Drug combination therapies have been devised to delay the development and spread of resistant malaria parasites. However, poor design often leads to ineffective combinations. Here, the properties of various drug combinations are reviewed in relationship to drug resistance and their pharmacokinetic compatibility.

AB - Drug combination therapies have been devised to delay the development and spread of resistant malaria parasites. However, poor design often leads to ineffective combinations. Here, the properties of various drug combinations are reviewed in relationship to drug resistance and their pharmacokinetic compatibility.

KW - Antifolates

KW - Artemisinin

KW - Drug combination therapy

KW - Drug resistance

KW - Malaria

KW - Quinolines

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U2 - 10.2174/138955708783744092

DO - 10.2174/138955708783744092

M3 - Review article

C2 - 18336340

AN - SCOPUS:42449137053

VL - 8

SP - 201

EP - 212

JO - Mini-Reviews in Medicinal Chemistry

JF - Mini-Reviews in Medicinal Chemistry

SN - 1389-5575

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ER -

Malaria combination therapies: Advantages and shortcomings

Abstract

Keywords

UN SDGs

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