Malaria combination therapies: Advantages and shortcomings

A. Martinelli, R. Moreira, P. V.L. Cravo

Research output: Contribution to journalReview articlepeer-review

37 Citations (Scopus)

Abstract

Drug combination therapies have been devised to delay the development and spread of resistant malaria parasites. However, poor design often leads to ineffective combinations. Here, the properties of various drug combinations are reviewed in relationship to drug resistance and their pharmacokinetic compatibility.

Original languageEnglish
Pages (from-to)201-212
Number of pages12
JournalMini-Reviews in Medicinal Chemistry
Volume8
Issue number3
DOIs
Publication statusPublished - 1 Mar 2008

Keywords

  • Antifolates
  • Artemisinin
  • Drug combination therapy
  • Drug resistance
  • Malaria
  • Quinolines

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