Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1

Adrian Cortes, Sara L. Pulit, Paul J. Leo, Jenny J. Pointon, Philip C. Robinson, Michael H. Weisman, Michael Ward, Lianne S. Gensler, Xiaodong Zhou, Henri Jean Garchon, Gilles Chiocchia, Johannes Nossent, Benedicte A. Lie, Øystein Førre, Jaakko Tuomilehto, Kari Laiho, Linda A. Bradbury, Dirk Elewaut, Ruben Burgos-Vargas, Simon StebbingsLouise Appleton, Claire Farrah, Jonathan Lau, Nigil Haroon, Juan Mulero, Francisco J. Blanco, Miguel A. Gonzalez-Gay, C. Lopez-Larrea, Paul Bowness, Karl Gaffney, Hill Gaston, Dafna D. Gladman, Proton Rahman, Walter P. Maksymowych, J. Bart A Crusius, Irene E. Van Der Horst-Bruinsma, Raphael Valle-Oñate, Consuelo Romero-Sánchez, Inger Myrnes Hansen, Fernando M. Pimentel-Santos, Robert D. Inman, Javier Martin, Maxime Breban, Bryan Paul Wordsworth, John D. Reveille, David M. Evans, Paul I W De Bakker, Matthew A. Brown

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

Ankylosing spondylitis (AS) is a common, highly heritable, inflammatory arthritis for which HLA-B∗27 is the major genetic risk factor, although its role in the aetiology of AS remains elusive. To better understand the genetic basis of the MHC susceptibility loci, we genotyped 7,264 MHC SNPs in 22,647 AS cases and controls of European descent. We impute SNPs, classical HLA alleles and amino-acid residues within HLA proteins, and tested these for association to AS status. Here we show that in addition to effects due to HLA-B∗27 alleles, several other HLA-B alleles also affect susceptibility. After controlling for the associated haplotypes in HLA-B, we observe independent associations with variants in the HLA-A, HLA-DPB1 and HLA-DRB1 loci. We also demonstrate that the ERAP1 SNP rs30187 association is not restricted only to carriers of HLA-B∗27 but also found in HLA-B∗40:01 carriers independently of HLA-B∗27 genotype.

Original languageEnglish
Article number7146
Pages (from-to)Online
Number of pages8
JournalNature Communications
Volume6
DOIs
Publication statusPublished - 21 May 2015

Keywords

  • UNFOLDED PROTEIN RESPONSE
  • GENOME-WIDE ASSOCIATION
  • SUSCEPTIBILITY LOCI
  • TRANSGENIC RATS
  • ENDOPLASMIC-RETICULUM
  • BEHCETS-DISEASE
  • HLA-B27
  • HLA
  • MHC
  • ANTIGEN

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