Magnetic Responsive PVA Hydrogels for Remote Modulation of Protein Sorption

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32 Citations (Scopus)


This work shows the ability to reversibly modulate the hydrophilicity of the hydrogels doped with iron oxide nanoparticles (MNPs) in a noninvasive way when exposed to a cyclic variation of the intensity (ON/OFF) of an external magnetic field. A reversible switching of surface contact angles was observed for magnetic PVA hydrogels when exposed to consecutive variation of the magnetic field intensity between 0 and 0.08 T. Motivated by the magnetic dependence of the hydrophilicity of these hybrid hydrogels, the impact of the magnetic field on protein sorption was also evaluated. The noninvasive regulation of protein sorption-released mechanisms was achieved by ON/OFF magnetic field switches, suggesting the possible influence of magnetic-induced hydrogel shrinking effect and changes of surface wettability on protein sorption. The capacity to magnetically modulate surface wettability and protein sorption make these magnetic hydrogels promising candidates for development of functional devices for tissue engineering, drug release applications, or biosensor systems, where the control of protein sorption and mobility are essential steps to improve the efficiency of these processes.

Original languageEnglish
Pages (from-to)21239-21249
Number of pages11
JournalACS Applied Materials & Interfaces
Issue number23
Publication statusPublished - 12 Jun 2019


  • ferrogel
  • magnetic field
  • membrane wettability
  • protein sorption
  • surface topography


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