Magnesium-Based Biodegradable Scaffolds for Bone Tissue Regeneration

Beatriz Oliveira, Ana Catarina Baptista, Cândida Malça, Joana Coutinho, Marta Henriques, Carla Moura

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Bone, one of the biggest tissues in our body, is complex and can regenerate itself when damaged. However, when the defects and traumas are of critical size, there is a lack of nutrients or mechanical impairment, which can avoid natural healing, leading to non-union fractures or atypical consolidation. For these reasons, biomaterials have been used to produce porous architectures, called scaffolds, with interconnectivity between pores, allowing the proliferation and adhesion of cells for the formation of new tissue and allowing bone recovery. Magnesium (Mg) appeared as a promising biomaterial for use in these situations, since it has good mechanical properties, similar to natural bone, and is biodegradable/bioresorbable. Thus, the main objective of this work was to produce biodegradable Mg-based scaffolds through three-dimensional (3D) printing (FDM) to be used in bone tissue regeneration. A comparison between two forms, oxide and sulphate, and two concentrations (5 and 15%) was used to understand which presents the most appropriate mechanical behaviour for in vivo implantation. Considering the compressive mechanical properties, results proved that 5% of Mg content present the highest compressive Young’s modulus in both forms.
Original languageEnglish
Title of host publicationProceedings of the 10th Congress of the Portuguese Society of Biomechanics
Subtitle of host publicationCNB 2023
EditorsAna Martins Amaro, Luís Roseiro, Ana Lúcia Messias, Beatriz Gomes, Henrique Almeida, Maria António Castro, Maria Augusta Neto, Maria de Fátima Paulino, Vítor Maranha
Place of PublicationCham
PublisherSpringer
Pages79-87
Number of pages9
ISBN (Electronic)978-3-031-47790-4
ISBN (Print)978-3-031-47789-8
DOIs
Publication statusPublished - Feb 2024
Event10th Congress of the Portuguese Society of Biomechanics, CNB 2023 - Figueira da Foz, Portugal
Duration: 5 May 20236 May 2023

Publication series

NameLecture Notes in Bioengineering
PublisherSpringer
ISSN (Print)2195-271X
ISSN (Electronic)2195-2728

Conference

Conference10th Congress of the Portuguese Society of Biomechanics, CNB 2023
Country/TerritoryPortugal
CityFigueira da Foz
Period5/05/236/05/23

Keywords

  • Additive manufacturing
  • Bone regeneration
  • Magnesium oxide
  • Magnesium sulphate
  • Scaffolds
  • Tissue engineering

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