TY - JOUR
T1 - Low prevalence of methicillin-resistant strains among Staphylococcus aureus colonizing young and healthy members of the community in Portugal
AU - Sá-Leão, Raquel
AU - Santos Sanches, Ilda
AU - Couto, Isabel Maria dos Santos Leitão
AU - de Lencastre, Herminia
PY - 2001/1/1
Y1 - 2001/1/1
N2 - Recent reports suggest that methicillin-resistant Staphylococcus aureus (MRSA) may be emerging as a com- munity pathogen. In Portuguese hospitals, the incidence of MRSA among disease causing isolates is extremely high (48–50%). To determine the prevalence of MRSA in the Portuguese community, nasal samples were ob- tained from 823 draftees, 484 nonmedical university students, and 107 high-school students. In addition, throat samples were obtained from the 823 draftees and S. aureus isolates were also recovered from 283 (13%) na- sopharyngeal samples obtained from 2,111 children attending day-care centers. The rate of nasal coloniza- tion of S. aureus was 34%, 25%, and 46% for draftees, nonmedical university students, and high-school stu- dents, respectively. The rate of pharyngeal colonization of the draftees was 33%. Of the 1,001 S. aureus isolates obtained, seven were MRSA and eight were borderline oxacillin-resistant S. aureus (BORSA). By molecular typing techniques, five of the seven MRSA were identified as belonging to one of three highly epidemic clones, the Brazilian, Iberian, and Pediatric clones of MRSA, which were identified as endemic in Portuguese hospi- tals. The eight BORSA were all members of clones previously identified in international samples. In spite of the extremely high prevalence of MRSA in Portuguese hospitals, the carriage rate of MRSA in healthy and young individuals remains low.
AB - Recent reports suggest that methicillin-resistant Staphylococcus aureus (MRSA) may be emerging as a com- munity pathogen. In Portuguese hospitals, the incidence of MRSA among disease causing isolates is extremely high (48–50%). To determine the prevalence of MRSA in the Portuguese community, nasal samples were ob- tained from 823 draftees, 484 nonmedical university students, and 107 high-school students. In addition, throat samples were obtained from the 823 draftees and S. aureus isolates were also recovered from 283 (13%) na- sopharyngeal samples obtained from 2,111 children attending day-care centers. The rate of nasal coloniza- tion of S. aureus was 34%, 25%, and 46% for draftees, nonmedical university students, and high-school stu- dents, respectively. The rate of pharyngeal colonization of the draftees was 33%. Of the 1,001 S. aureus isolates obtained, seven were MRSA and eight were borderline oxacillin-resistant S. aureus (BORSA). By molecular typing techniques, five of the seven MRSA were identified as belonging to one of three highly epidemic clones, the Brazilian, Iberian, and Pediatric clones of MRSA, which were identified as endemic in Portuguese hospi- tals. The eight BORSA were all members of clones previously identified in international samples. In spite of the extremely high prevalence of MRSA in Portuguese hospitals, the carriage rate of MRSA in healthy and young individuals remains low.
UR - http://www.scopus.com/inward/record.url?scp=0035179619&partnerID=8YFLogxK
U2 - 10.1089/10766290152652783
DO - 10.1089/10766290152652783
M3 - Article
SN - 1076-6294
VL - 7
SP - 237
EP - 245
JO - Microbial Drug Resistance
JF - Microbial Drug Resistance
IS - 3
ER -