Abstract
Age-associated pathophysiological changes such as neurodegenerative diseases are multifactorial conditions with increasing incidence and no existing cure. The possibility of altering the progression and development of these multifactorial diseases through diet is an attractive approach with increasing supporting data. Epidemiological and clinical studies have highlighted the health potential of diets rich in fruits and vegetables. Such food sources are rich in (poly)phenols, natural compounds increasingly associated with health benefits, having the potential to prevent or retard the development of various diseases. However, absorption and the blood concentration of (poly)phenols is very low when compared with their corresponding (poly)phenolic metabolites. Therefore, these serum-bioavailable metabolites are much more promising candidates to overcome cellular barriers and reach target tissues, such as the brain. Bearing this in mind, it will be reviewed that the molecular mechanisms underlying (poly)phenolic metabolites effects, range from 0.1 to <50 μM and their role on neuroinflammation, a central hallmark in neurodegenerative diseases.
| Original language | English |
|---|---|
| Journal | Journal of Agricultural and Food Chemistry |
| DOIs | |
| Publication status | Published - 1 Jan 2019 |
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Keywords
- brain
- flavonoid
- microbiota
- microglia
- neurodegenerative diseases
Cite this
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Low-Molecular Weight Metabolites from Polyphenols as Effectors for Attenuating Neuroinflammation. / Carregosa, Diogo; Carecho, Rafael; Figueira, Inês; Santos, Cláudia N.
In: Journal of Agricultural and Food Chemistry, 01.01.2019.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Low-Molecular Weight Metabolites from Polyphenols as Effectors for Attenuating Neuroinflammation
AU - Carregosa, Diogo
AU - Carecho, Rafael
AU - Figueira, Inês
AU - Santos, Cláudia N.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Age-associated pathophysiological changes such as neurodegenerative diseases are multifactorial conditions with increasing incidence and no existing cure. The possibility of altering the progression and development of these multifactorial diseases through diet is an attractive approach with increasing supporting data. Epidemiological and clinical studies have highlighted the health potential of diets rich in fruits and vegetables. Such food sources are rich in (poly)phenols, natural compounds increasingly associated with health benefits, having the potential to prevent or retard the development of various diseases. However, absorption and the blood concentration of (poly)phenols is very low when compared with their corresponding (poly)phenolic metabolites. Therefore, these serum-bioavailable metabolites are much more promising candidates to overcome cellular barriers and reach target tissues, such as the brain. Bearing this in mind, it will be reviewed that the molecular mechanisms underlying (poly)phenolic metabolites effects, range from 0.1 to <50 μM and their role on neuroinflammation, a central hallmark in neurodegenerative diseases.
AB - Age-associated pathophysiological changes such as neurodegenerative diseases are multifactorial conditions with increasing incidence and no existing cure. The possibility of altering the progression and development of these multifactorial diseases through diet is an attractive approach with increasing supporting data. Epidemiological and clinical studies have highlighted the health potential of diets rich in fruits and vegetables. Such food sources are rich in (poly)phenols, natural compounds increasingly associated with health benefits, having the potential to prevent or retard the development of various diseases. However, absorption and the blood concentration of (poly)phenols is very low when compared with their corresponding (poly)phenolic metabolites. Therefore, these serum-bioavailable metabolites are much more promising candidates to overcome cellular barriers and reach target tissues, such as the brain. Bearing this in mind, it will be reviewed that the molecular mechanisms underlying (poly)phenolic metabolites effects, range from 0.1 to <50 μM and their role on neuroinflammation, a central hallmark in neurodegenerative diseases.
KW - brain
KW - flavonoid
KW - microbiota
KW - microglia
KW - neurodegenerative diseases
UR - http://www.scopus.com/inward/record.url?scp=85070562223&partnerID=8YFLogxK
U2 - 10.1021/acs.jafc.9b02155
DO - 10.1021/acs.jafc.9b02155
M3 - Review article
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
SN - 0021-8561
ER -