14 Citations (Scopus)

Abstract

With aging, there is a decrease in parasympathetic nervous activity. Since the hepatic parasympathetic nerves (HPNs) are essential to the disposal of nutrients, through the hepatic insulin sensitizing substance (HISS), we tested the hypothesis that aging leads to a lowering of postprandial glucose disposal by a decrease of the HISS-dependent component of insulin action. Insulin sensitivity was quantified in fed or fasted, male and female Wistar rats (from 6 to 52 weeks), using a euglycemic clamp. The HISS-dependent component was quantified by administration of the muscarinic antagonist atropine. Total insulin action decreased gradually up to 52 weeks of age: The HISS-independent component of insulin action decreased until 9 weeks of age and remained unchanged thereafter; the HISS-dependent component decreased from 9 weeks of age throughout aging. The continuous decrease of HISS action, uncovered by blocking the HPN, is the key phenomenon for the gradual decrease of insulin sensitivity with aging.
Original languageUnknown
Pages (from-to)560-565
JournalJournals Of Gerontology Series A-Biological Sciences And Medical Sciences
Volume63
Issue number6
Publication statusPublished - 1 Jan 2008

Cite this

@article{daa6e7ba34634ef78883b5f8489464d1,
title = "Loss of postprandial insulin sensitization during aging",
abstract = "With aging, there is a decrease in parasympathetic nervous activity. Since the hepatic parasympathetic nerves (HPNs) are essential to the disposal of nutrients, through the hepatic insulin sensitizing substance (HISS), we tested the hypothesis that aging leads to a lowering of postprandial glucose disposal by a decrease of the HISS-dependent component of insulin action. Insulin sensitivity was quantified in fed or fasted, male and female Wistar rats (from 6 to 52 weeks), using a euglycemic clamp. The HISS-dependent component was quantified by administration of the muscarinic antagonist atropine. Total insulin action decreased gradually up to 52 weeks of age: The HISS-independent component of insulin action decreased until 9 weeks of age and remained unchanged thereafter; the HISS-dependent component decreased from 9 weeks of age throughout aging. The continuous decrease of HISS action, uncovered by blocking the HPN, is the key phenomenon for the gradual decrease of insulin sensitivity with aging.",
keywords = "type 2 diabetes mellitus, BLOCKADE, AGED RATS, GLUCOSE-UPTAKE, VAGAL TONE, RESISTANCE, MUSCLE, hepatic parasympathetic nerves, DIABETES-MELLITUS, SENSITIVITY, WISTAR RATS, NEUROPATHY, hepatic insulin sensitizing substance, insulin resistance",
author = "Ribeiro, {Rog{\'e}rio Jos{\'e} Tavares} and Afonso, {Ricardo Alexandre da Silva Santos} and Guarino, {Maria Pedro Sucena} and Macedo, {Maria Paula Borges de Lemos}",
year = "2008",
month = "1",
day = "1",
language = "Unknown",
volume = "63",
pages = "560--565",
journal = "Journals Of Gerontology Series A-Biological Sciences And Medical Sciences",
issn = "1079-5006",
publisher = "Gerontological Society of America",
number = "6",

}

TY - JOUR

T1 - Loss of postprandial insulin sensitization during aging

AU - Ribeiro, Rogério José Tavares

AU - Afonso, Ricardo Alexandre da Silva Santos

AU - Guarino, Maria Pedro Sucena

AU - Macedo, Maria Paula Borges de Lemos

PY - 2008/1/1

Y1 - 2008/1/1

N2 - With aging, there is a decrease in parasympathetic nervous activity. Since the hepatic parasympathetic nerves (HPNs) are essential to the disposal of nutrients, through the hepatic insulin sensitizing substance (HISS), we tested the hypothesis that aging leads to a lowering of postprandial glucose disposal by a decrease of the HISS-dependent component of insulin action. Insulin sensitivity was quantified in fed or fasted, male and female Wistar rats (from 6 to 52 weeks), using a euglycemic clamp. The HISS-dependent component was quantified by administration of the muscarinic antagonist atropine. Total insulin action decreased gradually up to 52 weeks of age: The HISS-independent component of insulin action decreased until 9 weeks of age and remained unchanged thereafter; the HISS-dependent component decreased from 9 weeks of age throughout aging. The continuous decrease of HISS action, uncovered by blocking the HPN, is the key phenomenon for the gradual decrease of insulin sensitivity with aging.

AB - With aging, there is a decrease in parasympathetic nervous activity. Since the hepatic parasympathetic nerves (HPNs) are essential to the disposal of nutrients, through the hepatic insulin sensitizing substance (HISS), we tested the hypothesis that aging leads to a lowering of postprandial glucose disposal by a decrease of the HISS-dependent component of insulin action. Insulin sensitivity was quantified in fed or fasted, male and female Wistar rats (from 6 to 52 weeks), using a euglycemic clamp. The HISS-dependent component was quantified by administration of the muscarinic antagonist atropine. Total insulin action decreased gradually up to 52 weeks of age: The HISS-independent component of insulin action decreased until 9 weeks of age and remained unchanged thereafter; the HISS-dependent component decreased from 9 weeks of age throughout aging. The continuous decrease of HISS action, uncovered by blocking the HPN, is the key phenomenon for the gradual decrease of insulin sensitivity with aging.

KW - type 2 diabetes mellitus

KW - BLOCKADE

KW - AGED RATS

KW - GLUCOSE-UPTAKE

KW - VAGAL TONE

KW - RESISTANCE

KW - MUSCLE

KW - hepatic parasympathetic nerves

KW - DIABETES-MELLITUS

KW - SENSITIVITY

KW - WISTAR RATS

KW - NEUROPATHY

KW - hepatic insulin sensitizing substance

KW - insulin resistance

M3 - Article

VL - 63

SP - 560

EP - 565

JO - Journals Of Gerontology Series A-Biological Sciences And Medical Sciences

JF - Journals Of Gerontology Series A-Biological Sciences And Medical Sciences

SN - 1079-5006

IS - 6

ER -