Longitudinal quantitative assessment of coronary atherosclerosis related to normal systolic blood pressure maintenance in the absence of established cardiovascular disease

Ki Bum Won; Hyung Bok Park; Ran Heo; Byoung Kwon Lee; Fay Y. Lin; Martin Hadamitzky; Yong Jin Kim; Ji Min Sung; Edoardo Conte; Daniele Andreini; Gianluca Pontone; Matthew J. Budoff; Ilan Gottlieb; Eun Ju Chun; Filippo Cademartiri; Erica Maffei; Hugo Marques; Pedro de Araújo Gonçalves; Jonathon A. Leipsic; Sang Eun Lee; Sanghoon Shin; Jung Hyun Choi; Renu Virmani; Habib Samady; Kavitha Chinnaiyan; Daniel S. Berman; Jagat Narula; Jeroen J. Bax; James K. Min; Hyuk Jae Chang

doi:10.1002/clc.23870

Longitudinal quantitative assessment of coronary atherosclerosis related to normal systolic blood pressure maintenance in the absence of established cardiovascular disease

Ki Bum Won, Hyung Bok Park, Ran Heo, Byoung Kwon Lee, Fay Y. Lin, Martin Hadamitzky, Yong Jin Kim, Ji Min Sung, Edoardo Conte, Daniele Andreini, Gianluca Pontone, Matthew J. Budoff, Ilan Gottlieb, Eun Ju Chun, Filippo Cademartiri, Erica Maffei, Hugo Marques, Pedro de Araújo Gonçalves, Jonathon A. Leipsic, Sang Eun LeeSanghoon Shin, Jung Hyun Choi, Renu Virmani, Habib Samady, Kavitha Chinnaiyan, Daniel S. Berman, Jagat Narula, Jeroen J. Bax, James K. Min, Hyuk Jae Chang

NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

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2 Citations (Scopus)

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Abstract

Background: Atherosclerosis-related adverse events are commonly observed even in conditions with low cardiovascular (CV) risk. Longitudinal data regarding the association of normal systolic blood pressure maintenance (SBP_maintain) with coronary plaque volume changes (PVC) has been limited in adults without traditional CV disease. Hypothesis: Normal SBP_maintain is important to attenuate coronary atherosclerosis progression in adults without baseline CV disease. Methods: We analyzed 95 adults (56.7 ± 8.5 years; 40.0% men) without baseline CV disease who underwent serial coronary computed tomographic angiography with mean 3.5 years of follow-up. All participants were divided into two groups of normal SBP_maintain (follow-up SBP < 120 mm Hg) and ≥elevated SBP_maintain (follow-up SBP ≥ 120 mm Hg). Annualized PVC was defined as PVC divided by the interscan period. Results: Compared to participants with normal SBP_maintain, those with ≥elevated SBP_maintain had higher annualized total PVC (mm³/year) (0.0 [0.0–2.2] vs. 4.1 [0.0–13.0]; p <.001). Baseline total plaque volume (β =.10) and the levels of SBP_maintain (β =.23) and follow-up high-density lipoprotein cholesterol (β = −0.28) were associated with annualized total PVC (all p <.05). The optimal cutoff of SBP_maintain for predicting plaque progression was 118.5 mm Hg (sensitivity: 78.2%, specificity: 62.5%; area under curve: 0.700; 95% confidence interval [CI]: 0.59–0.81; p <.05). SBP_maintain ≥ 118.5 mm Hg (odds ratio [OR]: 4.03; 95% CI: 1.51–10.75) and baseline total plaque volume (OR: 1.03; 95% CI: 1.01–1.06) independently influenced coronary plaque progression (all p <.05). Conclusion: Normal SBP_maintain is substantial to attenuate coronary atherosclerosis progression in conditions without established CV disease.

Original language	English
Pages (from-to)	873-881
Journal	Clinical Cardiology
Volume	45
Issue number	8
Early online date	2022
DOIs	https://doi.org/10.1002/clc.23870
Publication status	Published - Aug 2022

Keywords

atherosclerosis
coronary artery disease
coronary computed tomography angiography
systolic blood pressure

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/clc.23870

Clinical Cardiology - 2022 - Won - Longitudinal quantitative assessment of coronary atherosclerosis related to normalFinal published version, 1.42 MBLicence: CC BY

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Won, K. B., Park, H. B., Heo, R., Lee, B. K., Lin, F. Y., Hadamitzky, M., Kim, Y. J., Sung, J. M., Conte, E., Andreini, D., Pontone, G., Budoff, M. J., Gottlieb, I., Chun, E. J., Cademartiri, F., Maffei, E., Marques, H., Gonçalves, P. D. A., Leipsic, J. A., ... Chang, H. J. (2022). Longitudinal quantitative assessment of coronary atherosclerosis related to normal systolic blood pressure maintenance in the absence of established cardiovascular disease. Clinical Cardiology, 45(8), 873-881. Advance online publication. https://doi.org/10.1002/clc.23870

@article{cf02746e04434db387a5f22989eae401,

title = "Longitudinal quantitative assessment of coronary atherosclerosis related to normal systolic blood pressure maintenance in the absence of established cardiovascular disease",

abstract = "Background: Atherosclerosis-related adverse events are commonly observed even in conditions with low cardiovascular (CV) risk. Longitudinal data regarding the association of normal systolic blood pressure maintenance (SBPmaintain) with coronary plaque volume changes (PVC) has been limited in adults without traditional CV disease. Hypothesis: Normal SBPmaintain is important to attenuate coronary atherosclerosis progression in adults without baseline CV disease. Methods: We analyzed 95 adults (56.7 ± 8.5 years; 40.0% men) without baseline CV disease who underwent serial coronary computed tomographic angiography with mean 3.5 years of follow-up. All participants were divided into two groups of normal SBPmaintain (follow-up SBP < 120 mm Hg) and ≥elevated SBPmaintain (follow-up SBP ≥ 120 mm Hg). Annualized PVC was defined as PVC divided by the interscan period. Results: Compared to participants with normal SBPmaintain, those with ≥elevated SBPmaintain had higher annualized total PVC (mm3/year) (0.0 [0.0–2.2] vs. 4.1 [0.0–13.0]; p <.001). Baseline total plaque volume (β =.10) and the levels of SBPmaintain (β =.23) and follow-up high-density lipoprotein cholesterol (β = −0.28) were associated with annualized total PVC (all p <.05). The optimal cutoff of SBPmaintain for predicting plaque progression was 118.5 mm Hg (sensitivity: 78.2%, specificity: 62.5%; area under curve: 0.700; 95% confidence interval [CI]: 0.59–0.81; p <.05). SBPmaintain ≥ 118.5 mm Hg (odds ratio [OR]: 4.03; 95% CI: 1.51–10.75) and baseline total plaque volume (OR: 1.03; 95% CI: 1.01–1.06) independently influenced coronary plaque progression (all p <.05). Conclusion: Normal SBPmaintain is substantial to attenuate coronary atherosclerosis progression in conditions without established CV disease.",

keywords = "atherosclerosis, coronary artery disease, coronary computed tomography angiography, systolic blood pressure",

author = "Won, {Ki Bum} and Park, {Hyung Bok} and Ran Heo and Lee, {Byoung Kwon} and Lin, {Fay Y.} and Martin Hadamitzky and Kim, {Yong Jin} and Sung, {Ji Min} and Edoardo Conte and Daniele Andreini and Gianluca Pontone and Budoff, {Matthew J.} and Ilan Gottlieb and Chun, {Eun Ju} and Filippo Cademartiri and Erica Maffei and Hugo Marques and Gon{\c c}alves, {Pedro de Ara{\'u}jo} and Leipsic, {Jonathon A.} and Lee, {Sang Eun} and Sanghoon Shin and Choi, {Jung Hyun} and Renu Virmani and Habib Samady and Kavitha Chinnaiyan and Berman, {Daniel S.} and Jagat Narula and Bax, {Jeroen J.} and Min, {James K.} and Chang, {Hyuk Jae}",

note = "Funding Information: The project was conducted within the framework of a {"}Multidisciplinary Survey and Monitoring of the Gareja Rock Cut Complex, the Monument of National Value{"} funded by the National Agency for Cultural Heritage Preservation of Georgia and managed by the Ilia State University, Georgia, together with the Italian Institute for Environmental Protection and Research, Italy, and the support of the University of Milano-Bicocca, Italy. Data used in this work was jointly acquired and, accordingly, belongs to all three institutions. ",

year = "2022",

month = aug,

doi = "10.1002/clc.23870",

language = "English",

volume = "45",

pages = "873--881",

journal = "Clinical Cardiology",

issn = "0160-9289",

publisher = "Wiley",

number = "8",

}

Won, KB, Park, HB, Heo, R, Lee, BK, Lin, FY, Hadamitzky, M, Kim, YJ, Sung, JM, Conte, E, Andreini, D, Pontone, G, Budoff, MJ, Gottlieb, I, Chun, EJ, Cademartiri, F, Maffei, E, Marques, H, Gonçalves, PDA, Leipsic, JA, Lee, SE, Shin, S, Choi, JH, Virmani, R, Samady, H, Chinnaiyan, K, Berman, DS, Narula, J, Bax, JJ, Min, JK & Chang, HJ 2022, 'Longitudinal quantitative assessment of coronary atherosclerosis related to normal systolic blood pressure maintenance in the absence of established cardiovascular disease', Clinical Cardiology, vol. 45, no. 8, pp. 873-881. https://doi.org/10.1002/clc.23870

TY - JOUR

T1 - Longitudinal quantitative assessment of coronary atherosclerosis related to normal systolic blood pressure maintenance in the absence of established cardiovascular disease

AU - Won, Ki Bum

AU - Park, Hyung Bok

AU - Heo, Ran

AU - Lee, Byoung Kwon

AU - Lin, Fay Y.

AU - Hadamitzky, Martin

AU - Kim, Yong Jin

AU - Sung, Ji Min

AU - Conte, Edoardo

AU - Andreini, Daniele

AU - Pontone, Gianluca

AU - Budoff, Matthew J.

AU - Gottlieb, Ilan

AU - Chun, Eun Ju

AU - Cademartiri, Filippo

AU - Maffei, Erica

AU - Marques, Hugo

AU - Gonçalves, Pedro de Araújo

AU - Leipsic, Jonathon A.

AU - Lee, Sang Eun

AU - Shin, Sanghoon

AU - Choi, Jung Hyun

AU - Virmani, Renu

AU - Samady, Habib

AU - Chinnaiyan, Kavitha

AU - Berman, Daniel S.

AU - Narula, Jagat

AU - Bax, Jeroen J.

AU - Min, James K.

AU - Chang, Hyuk Jae

N1 - Funding Information: The project was conducted within the framework of a "Multidisciplinary Survey and Monitoring of the Gareja Rock Cut Complex, the Monument of National Value" funded by the National Agency for Cultural Heritage Preservation of Georgia and managed by the Ilia State University, Georgia, together with the Italian Institute for Environmental Protection and Research, Italy, and the support of the University of Milano-Bicocca, Italy. Data used in this work was jointly acquired and, accordingly, belongs to all three institutions.

PY - 2022/8

Y1 - 2022/8

N2 - Background: Atherosclerosis-related adverse events are commonly observed even in conditions with low cardiovascular (CV) risk. Longitudinal data regarding the association of normal systolic blood pressure maintenance (SBPmaintain) with coronary plaque volume changes (PVC) has been limited in adults without traditional CV disease. Hypothesis: Normal SBPmaintain is important to attenuate coronary atherosclerosis progression in adults without baseline CV disease. Methods: We analyzed 95 adults (56.7 ± 8.5 years; 40.0% men) without baseline CV disease who underwent serial coronary computed tomographic angiography with mean 3.5 years of follow-up. All participants were divided into two groups of normal SBPmaintain (follow-up SBP < 120 mm Hg) and ≥elevated SBPmaintain (follow-up SBP ≥ 120 mm Hg). Annualized PVC was defined as PVC divided by the interscan period. Results: Compared to participants with normal SBPmaintain, those with ≥elevated SBPmaintain had higher annualized total PVC (mm3/year) (0.0 [0.0–2.2] vs. 4.1 [0.0–13.0]; p <.001). Baseline total plaque volume (β =.10) and the levels of SBPmaintain (β =.23) and follow-up high-density lipoprotein cholesterol (β = −0.28) were associated with annualized total PVC (all p <.05). The optimal cutoff of SBPmaintain for predicting plaque progression was 118.5 mm Hg (sensitivity: 78.2%, specificity: 62.5%; area under curve: 0.700; 95% confidence interval [CI]: 0.59–0.81; p <.05). SBPmaintain ≥ 118.5 mm Hg (odds ratio [OR]: 4.03; 95% CI: 1.51–10.75) and baseline total plaque volume (OR: 1.03; 95% CI: 1.01–1.06) independently influenced coronary plaque progression (all p <.05). Conclusion: Normal SBPmaintain is substantial to attenuate coronary atherosclerosis progression in conditions without established CV disease.

AB - Background: Atherosclerosis-related adverse events are commonly observed even in conditions with low cardiovascular (CV) risk. Longitudinal data regarding the association of normal systolic blood pressure maintenance (SBPmaintain) with coronary plaque volume changes (PVC) has been limited in adults without traditional CV disease. Hypothesis: Normal SBPmaintain is important to attenuate coronary atherosclerosis progression in adults without baseline CV disease. Methods: We analyzed 95 adults (56.7 ± 8.5 years; 40.0% men) without baseline CV disease who underwent serial coronary computed tomographic angiography with mean 3.5 years of follow-up. All participants were divided into two groups of normal SBPmaintain (follow-up SBP < 120 mm Hg) and ≥elevated SBPmaintain (follow-up SBP ≥ 120 mm Hg). Annualized PVC was defined as PVC divided by the interscan period. Results: Compared to participants with normal SBPmaintain, those with ≥elevated SBPmaintain had higher annualized total PVC (mm3/year) (0.0 [0.0–2.2] vs. 4.1 [0.0–13.0]; p <.001). Baseline total plaque volume (β =.10) and the levels of SBPmaintain (β =.23) and follow-up high-density lipoprotein cholesterol (β = −0.28) were associated with annualized total PVC (all p <.05). The optimal cutoff of SBPmaintain for predicting plaque progression was 118.5 mm Hg (sensitivity: 78.2%, specificity: 62.5%; area under curve: 0.700; 95% confidence interval [CI]: 0.59–0.81; p <.05). SBPmaintain ≥ 118.5 mm Hg (odds ratio [OR]: 4.03; 95% CI: 1.51–10.75) and baseline total plaque volume (OR: 1.03; 95% CI: 1.01–1.06) independently influenced coronary plaque progression (all p <.05). Conclusion: Normal SBPmaintain is substantial to attenuate coronary atherosclerosis progression in conditions without established CV disease.

KW - atherosclerosis

KW - coronary artery disease

KW - coronary computed tomography angiography

KW - systolic blood pressure

UR - http://www.scopus.com/inward/record.url?scp=85131588133&partnerID=8YFLogxK

U2 - 10.1002/clc.23870

DO - 10.1002/clc.23870

M3 - Article

C2 - 35673995

AN - SCOPUS:85131588133

SN - 0160-9289

VL - 45

SP - 873

EP - 881

JO - Clinical Cardiology

JF - Clinical Cardiology

IS - 8

ER -

Longitudinal quantitative assessment of coronary atherosclerosis related to normal systolic blood pressure maintenance in the absence of established cardiovascular disease

Abstract

Keywords

UN SDGs

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