Long-term exposure to low doses of aluminum affects mineral content and microarchitecture of rats alveolar bone

Deiweson Souza-Monteiro, Railson de Oliveira Ferreira, Luciana Guimarães Eiró, Leidiane Alencar de Oliveira Lima, Gabriela Souza Balbinot, Simone Patricia Aranha da Paz, Alan Rodrigo Leal Albuquerque, Fabricio Mezzomo Collares, Rômulo Simões Angélica, Sofia Pessanha, Cristiane do Socorro Ferraz Maia, Rafael Rodrigues Lima

Research output: Contribution to journalArticlepeer-review


Aluminum (Al) is one of the most found elements in nature in many forms, and human exposure can be quite common. Therefore, it is important to investigate the effects of exposure to Al mainly at low doses and for a prolonged period, in order to simulate human exposure in the periodontium, an important structure for support and protection of the teeth. This investigation aimed to study the aluminum chloride (AlCl3) toxicological effects in the mineral composition and micromorphology of the alveolar bone of rats. Two groups of eight male Wistar rats were used for the experiment. AlCl3 group was exposed to AlCl3 orally at a dose of 8.3 mg/kg/day for 60 days, while the control group received only distilled water. After that, the mandibles were collected and submitted to the following analyses: Fourier transform infrared spectroscopy, Raman spectroscopy, and X-ray microtomography analysis; blood was also collected for determination of Al circulating levels. Our data showed that AlCl3 was capable of increasing Al circulating levels in blood. It was able to promote changes in the mineral content and triggers significant changes in the mineralized bone microstructure, such as number and thickness of trabeculae, being associated with alveolar bone-loss.

Original languageEnglish
Pages (from-to)45879-45890
JournalEnvironmental Science and Pollution Research
Issue number33
Publication statusPublished - Sep 2021


  • Aluminum chloride
  • Alveolar bone
  • Bone loss
  • MicroCT
  • Raman spectroscopy
  • Toxicology


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