Living and thriving on the skin

Malassezia genomes tell the story

Research output: Contribution to journalComment/debate

8 Citations (Scopus)

Abstract

Our understanding of the interactions between normal skin microbiota and the human host has been greatly extended by recent investigations. In their recent study in mBio, A. Gioti et al. (mBio 4[1]:e00572-12, 2013) sequenced the genome of the atopic eczema-associated yeast, Malassezia sympodialis, and compared its gene content and organization with that of Malassezia globosa, a species implicated in dandruff. Their findings were also contrasted with those previously obtained for Ustilago maydis, which is a close relative but ecologically distinct plant parasite. Besides gaining additional insight into key hostspecific adaptations and the particular function and molecular evolution of allergens related to atopic eczema, Gioti et al. also uncovered several lines of evidence that elegantly suggest the presence of an extant sexual cycle, with important implications in disease.

Original languageEnglish
Article numbere00117-13
JournalmBio
Volume4
Issue number2
DOIs
Publication statusPublished - Mar 2013

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Malassezia
Atopic Dermatitis
Dandruff
Ustilago
Genome
Skin
Molecular Evolution
Microbiota
Allergens
Parasites
Yeasts
Genes

Cite this

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title = "Living and thriving on the skin: Malassezia genomes tell the story",
abstract = "Our understanding of the interactions between normal skin microbiota and the human host has been greatly extended by recent investigations. In their recent study in mBio, A. Gioti et al. (mBio 4[1]:e00572-12, 2013) sequenced the genome of the atopic eczema-associated yeast, Malassezia sympodialis, and compared its gene content and organization with that of Malassezia globosa, a species implicated in dandruff. Their findings were also contrasted with those previously obtained for Ustilago maydis, which is a close relative but ecologically distinct plant parasite. Besides gaining additional insight into key hostspecific adaptations and the particular function and molecular evolution of allergens related to atopic eczema, Gioti et al. also uncovered several lines of evidence that elegantly suggest the presence of an extant sexual cycle, with important implications in disease.",
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Living and thriving on the skin : Malassezia genomes tell the story. / Coelho, Marco A.; Sampaio, José Paulo; Gonçalves, Paula.

In: mBio, Vol. 4, No. 2, e00117-13, 03.2013.

Research output: Contribution to journalComment/debate

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AU - Sampaio, José Paulo

AU - Gonçalves, Paula

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