TY - JOUR
T1 - Liquid biopsies in myeloid malignancies
AU - Abdulmawjood, Bilal R.
AU - Roma-Rodrigues, Catarina
AU - Fernandes, Alexandra R.
AU - Baptista, Pedro V.
N1 - info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04378%2F2019/PT#
PY - 2019
Y1 - 2019
N2 - Hematologic malignancies are the most common type of cancer affecting children and young adults, and encompass diseases, such as leukemia, lymphoma, and myeloma, all of which impact blood associated tissues such as the bone marrow, lymphatic system, and blood cells. Clinical diagnostics of these malignancies relies heavily on the use of bone marrow samples, which is painful, debilitating, and not free from risks for leukemia patients. Liquid biopsies are based on minimally invasive assessment of markers in the blood (and other fluids) and have the potential to improve the efficacy of diagnostic/therapeutic strategies in leukemia patients, providing a useful tool for the real time molecular profiling of patients. The most promising noninvasive biomarkers are circulating tumor cells, circulating tumor DNA, microRNAs, and exosomes. Herein, we discuss the role of assessing these circulating biomarkers for the understanding of tumor progression and metastasis, tumor progression dynamics through treatment and for follow-up.
AB - Hematologic malignancies are the most common type of cancer affecting children and young adults, and encompass diseases, such as leukemia, lymphoma, and myeloma, all of which impact blood associated tissues such as the bone marrow, lymphatic system, and blood cells. Clinical diagnostics of these malignancies relies heavily on the use of bone marrow samples, which is painful, debilitating, and not free from risks for leukemia patients. Liquid biopsies are based on minimally invasive assessment of markers in the blood (and other fluids) and have the potential to improve the efficacy of diagnostic/therapeutic strategies in leukemia patients, providing a useful tool for the real time molecular profiling of patients. The most promising noninvasive biomarkers are circulating tumor cells, circulating tumor DNA, microRNAs, and exosomes. Herein, we discuss the role of assessing these circulating biomarkers for the understanding of tumor progression and metastasis, tumor progression dynamics through treatment and for follow-up.
KW - Circulating tumor cells
KW - Circulating tumor DNA
KW - Exosomes
KW - Leukemia
KW - Liquid biopsy
KW - MicroRNAs
UR - http://www.scopus.com/inward/record.url?scp=85107446685&partnerID=8YFLogxK
U2 - 10.20517/cdr.2019.88
DO - 10.20517/cdr.2019.88
M3 - Review article
AN - SCOPUS:85107446685
SN - 2578-532X
VL - 2
SP - 1044
EP - 1061
JO - Cancer Drug Resistance
JF - Cancer Drug Resistance
IS - 4
ER -