TY - JOUR
T1 - Linking chemical exposure and fish metabolome
T2 - Discovering new biomarkers of environmental exposure of Argyrosomus regius to the antidepressant venlafaxine
AU - Santos, Lúcia H. M. L. M.
AU - Maulvault, Ana Luísa
AU - Jaén-Gil, Adrián
AU - Marques, António
AU - Barceló, Damià
AU - Rodríguez-Mozaz, Sara
N1 - Funding Information:
This work was funded by the 7th EU-FP (ECsafeSEAFOOD project; GA n° 311820 ) and the European Regional Development Fund (FEDER) and by Spanish Ministry of Economy and Competitiveness ( PGE-2010 ). Lúcia H.M.L.M. Santos thanks the Juan de la Cierva program (IJCI-2017-32747) from the Spanish State Research Agency of the Spanish Ministry of Science, Innovation and Universities ( AEI-MCIU ).
Publisher Copyright:
© 2023 Elsevier B.V.
PY - 2023/3
Y1 - 2023/3
N2 - In this study, a non-target metabolomic approach was used to investigate changes in the metabolome of juvenile meagre (Argyrosomus regius) exposed to venlafaxine (20 µg/L). A total of 24, 22 and 8 endogenous metabolites tentatively identified in liver, brain and plasma, respectively, were significantly changed in venlafaxine exposed meagre, showing tissue-dependent variations in the metabolic profile. The amino acids tryptophan, tyrosine and phenylalanine, which are related to the synthesis, availability, and expression of neurotransmitters (e.g., serotonin, dopamine, epinephrine), showed to be dysregulated by venlafaxine exposure. A high impact was observed in fish brain metabolome that showed a trend of up-regulation for most of the tentatively identified metabolites. In conclusion, the identification of possible biomarkers of exposure in fish metabolome to environmental stressors such as venlafaxine is crucial to assess early signal changes at molecular level, enabling the prevention of deleterious effects at the organism and population levels.
AB - In this study, a non-target metabolomic approach was used to investigate changes in the metabolome of juvenile meagre (Argyrosomus regius) exposed to venlafaxine (20 µg/L). A total of 24, 22 and 8 endogenous metabolites tentatively identified in liver, brain and plasma, respectively, were significantly changed in venlafaxine exposed meagre, showing tissue-dependent variations in the metabolic profile. The amino acids tryptophan, tyrosine and phenylalanine, which are related to the synthesis, availability, and expression of neurotransmitters (e.g., serotonin, dopamine, epinephrine), showed to be dysregulated by venlafaxine exposure. A high impact was observed in fish brain metabolome that showed a trend of up-regulation for most of the tentatively identified metabolites. In conclusion, the identification of possible biomarkers of exposure in fish metabolome to environmental stressors such as venlafaxine is crucial to assess early signal changes at molecular level, enabling the prevention of deleterious effects at the organism and population levels.
KW - Aquatic organisms
KW - Ecotoxicology
KW - Molecular effects
KW - Non-target metabolomics
KW - Pharmaceuticals
UR - http://www.scopus.com/inward/record.url?scp=85146096079&partnerID=8YFLogxK
U2 - 10.1016/j.etap.2023.104063
DO - 10.1016/j.etap.2023.104063
M3 - Article
C2 - 36623700
AN - SCOPUS:85146096079
SN - 1382-6689
VL - 98
JO - Environmental toxicology and pharmacology
JF - Environmental toxicology and pharmacology
M1 - 104063
ER -