Linking chemical exposure and fish metabolome: Discovering new biomarkers of environmental exposure of Argyrosomus regius to the antidepressant venlafaxine

Lúcia H. M. L. M. Santos, Ana Luísa Maulvault, Adrián Jaén-Gil, António Marques, Damià Barceló, Sara Rodríguez-Mozaz

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

In this study, a non-target metabolomic approach was used to investigate changes in the metabolome of juvenile meagre (Argyrosomus regius) exposed to venlafaxine (20 µg/L). A total of 24, 22 and 8 endogenous metabolites tentatively identified in liver, brain and plasma, respectively, were significantly changed in venlafaxine exposed meagre, showing tissue-dependent variations in the metabolic profile. The amino acids tryptophan, tyrosine and phenylalanine, which are related to the synthesis, availability, and expression of neurotransmitters (e.g., serotonin, dopamine, epinephrine), showed to be dysregulated by venlafaxine exposure. A high impact was observed in fish brain metabolome that showed a trend of up-regulation for most of the tentatively identified metabolites. In conclusion, the identification of possible biomarkers of exposure in fish metabolome to environmental stressors such as venlafaxine is crucial to assess early signal changes at molecular level, enabling the prevention of deleterious effects at the organism and population levels.

Original languageEnglish
Article number104063
Number of pages8
JournalEnvironmental toxicology and pharmacology
Volume98
DOIs
Publication statusPublished - Mar 2023

Keywords

  • Aquatic organisms
  • Ecotoxicology
  • Molecular effects
  • Non-target metabolomics
  • Pharmaceuticals

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