Leveraging antimicrobial stewardship: focus on individual prescriptions appropriateness

Carlos Palos, Paulo Sousa

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Antimicrobial resistance and healthcare associated infections are major worldwide Public Health and Patient Safety challenges. Inappropriate antibiotic prescription is the major drive for antibiotic resistance and is present in 30 to 50% of all antibiotic prescriptions. However, adherence to guidelines and to computerized decision support systems is still poor, reflecting the complexity of the prescription process. Antimicrobial stewardship programs have been implemented aiming optimization of prescriptions. Assessment of individual prescriptions appropriateness is a major task and a pillar of these programs. Adoption of universal definitions of appropriateness and assessments, based on quality indicators, metrics and algorithms, is needed in order to improve classifications of individual prescriptions and its determinants, where new eHealth tools and ultimately artificial intelligence will be major allies. This text highlights the importance of evaluation of individual prescriptions as the major way to understand the determinants of (in)appropriate antibiotic prescription and the need for future developments. It mainly results from a comprehensive review of papers published since 2010, related to antimicrobial resistance, the prescription process, antimicrobial stewardship, as well the appropriateness of antibiotic prescription and its evaluation. The road is ahead!.

Original languageEnglish
Title of host publicationHealth and social care systems of the future
Subtitle of host publicationdemographic changes, digital age and human factors: proceedings of the Healthcare Ergonomics and Patient Safety, HEPS 2019
EditorsTeresa Patrone Cotrim, Florentino Serranheira, Paulo Sousa, Sue Hignett, Sara Albolino, Riccardo Tartaglia
PublisherSpringer Verlag
Number of pages8
ISBN (Print)9783030240660
Publication statusPublished - 1 Jan 2019
EventInternational Conference on Healthcare Ergonomics and Patient Safety, HEPS 2019 - Lisbon, Portugal
Duration: 3 Jul 20195 Jul 2019

Publication series

NameAdvances in Intelligent Systems and Computing
ISSN (Print)2194-5357


ConferenceInternational Conference on Healthcare Ergonomics and Patient Safety, HEPS 2019


  • Antimicrobial stewardship
  • Appropriateness
  • Patient safety


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