Leishmaniosis: new insights in a changing world

G. Alexandre-pires; M. Santos; M. A. Rodrigues; M. A. Pereira; J. Gomes; S. A. Diaz; L. Gomes; A. Basso; A. Reisinho; J. Gomes; R. Leal; J. Correia; A. Bolas; J. Meireles; G. Santos-gomes; I. Pereira-da-fonseca

doi:10.1007/978-3-030-61981-7_17

Leishmaniosis: new insights in a changing world

G. Alexandre-pires, M. Santos, M. A. Rodrigues, M. A. Pereira, J. Gomes, S. A. Diaz, L. Gomes, A. Basso, A. Reisinho, J. Gomes, R. Leal, J. Correia, A. Bolas, J. Meireles, G. Santos-gomes, I. Pereira-da-fonseca

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Canine leishmaniosis caused by Leishmania infantum is a zoonotic disease of serious veterinary concern in the Mediterranean basin. In Portugal has been reported in dogs, cats and synanthropic rodents. Epidemiological changes and new hosts may contribute to increase zoonotic risk. A better knowledge on immune response, treatment and diagnosis are at the forefront of research on this disease. Host immune response is multifactorial, reflecting the organ specificity. Macrophages (MØ) are the definitive host cells, although neutrophils (PMN) are the first cells to encounter parasites soon after inoculation in the dermis. The PMN-parasite interaction decreases parasite viability, but PMN-MØ interaction induces nitric oxide production and release of neutrophil extracellular traps that contain parasites, controlling dog infection at early stages. Liver resident Kupffer cells (KC) efficiently phagocyte Leishmania by establishing an intimate contact with circulating blood. The impact of meglumine antimoniate (MG) over infected canine KC was investigated. The effect of different treatment protocols in dog’s immune response was assessed. MG+miltefosine treatments plus allopurinol restore lymphokine gene expression, pointing through a drug-induced reduction of anti-inflammatory and regulatory cytokines. Furthermore, increasing feline leishmaniosis and the inconsistent results of therapeutic protocols led the team to evaluate their safety and effectiveness in cat.

Original language	English
Title of host publication	Advances in animal health, medicine and production
Subtitle of host publication	a research portrait of the Centre for Interdisciplinary Research in Animal Health (CIISA), University of Lisbon, Portugal
Editors	Antonio Freitas Duarte, Luís Lopes da Costa
Publisher	Springer International Publishing AG
Chapter	17
Pages	301-320
Number of pages	20
ISBN (Electronic)	978-3-030-61981-7
ISBN (Print)	978-3-030-61980-0
DOIs	https://doi.org/10.1007/978-3-030-61981-7_17
Publication status	Published - 22 Nov 2020

Keywords

Leishmania
Leishmaniosis
Host-immune-response
Zoonosis
Treatment

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-3-030-61981-7_17

Cite this

Alexandre-pires, G., Santos, M., Rodrigues, M. A., Pereira, M. A., Gomes, J., Diaz, S. A., Gomes, L., Basso, A., Reisinho, A., Gomes, J., Leal, R., Correia, J., Bolas, A., Meireles, J., Santos-gomes, G., & Pereira-da-fonseca, I. (2020). Leishmaniosis: new insights in a changing world. In A. Freitas Duarte, & L. Lopes da Costa (Eds.), Advances in animal health, medicine and production: a research portrait of the Centre for Interdisciplinary Research in Animal Health (CIISA), University of Lisbon, Portugal (pp. 301-320). Springer International Publishing AG. https://doi.org/10.1007/978-3-030-61981-7_17

Alexandre-pires, G. ; Santos, M. ; Rodrigues, M. A. et al. / Leishmaniosis : new insights in a changing world. Advances in animal health, medicine and production: a research portrait of the Centre for Interdisciplinary Research in Animal Health (CIISA), University of Lisbon, Portugal. editor / Antonio Freitas Duarte ; Luís Lopes da Costa. Springer International Publishing AG, 2020. pp. 301-320

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abstract = "Canine leishmaniosis caused by Leishmania infantum is a zoonotic disease of serious veterinary concern in the Mediterranean basin. In Portugal has been reported in dogs, cats and synanthropic rodents. Epidemiological changes and new hosts may contribute to increase zoonotic risk. A better knowledge on immune response, treatment and diagnosis are at the forefront of research on this disease. Host immune response is multifactorial, reflecting the organ specificity. Macrophages (M{\O}) are the definitive host cells, although neutrophils (PMN) are the first cells to encounter parasites soon after inoculation in the dermis. The PMN-parasite interaction decreases parasite viability, but PMN-M{\O} interaction induces nitric oxide production and release of neutrophil extracellular traps that contain parasites, controlling dog infection at early stages. Liver resident Kupffer cells (KC) efficiently phagocyte Leishmania by establishing an intimate contact with circulating blood. The impact of meglumine antimoniate (MG) over infected canine KC was investigated. The effect of different treatment protocols in dog{\textquoteright}s immune response was assessed. MG+miltefosine treatments plus allopurinol restore lymphokine gene expression, pointing through a drug-induced reduction of anti-inflammatory and regulatory cytokines. Furthermore, increasing feline leishmaniosis and the inconsistent results of therapeutic protocols led the team to evaluate their safety and effectiveness in cat.",

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author = "G. Alexandre-pires and M. Santos and Rodrigues, {M. A.} and Pereira, {M. A.} and J. Gomes and Diaz, {S. A.} and L. Gomes and A. Basso and A. Reisinho and J. Gomes and R. Leal and J. Correia and A. Bolas and J. Meireles and G. Santos-gomes and I. Pereira-da-fonseca",

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Alexandre-pires, G, Santos, M, Rodrigues, MA, Pereira, MA, Gomes, J, Diaz, SA, Gomes, L, Basso, A, Reisinho, A, Gomes, J, Leal, R, Correia, J, Bolas, A, Meireles, J, Santos-gomes, G & Pereira-da-fonseca, I 2020, Leishmaniosis: new insights in a changing world. in A Freitas Duarte & L Lopes da Costa (eds), Advances in animal health, medicine and production: a research portrait of the Centre for Interdisciplinary Research in Animal Health (CIISA), University of Lisbon, Portugal. Springer International Publishing AG, pp. 301-320. https://doi.org/10.1007/978-3-030-61981-7_17

Leishmaniosis: new insights in a changing world. / Alexandre-pires, G.; Santos, M.; Rodrigues, M. A. et al.
Advances in animal health, medicine and production: a research portrait of the Centre for Interdisciplinary Research in Animal Health (CIISA), University of Lisbon, Portugal. ed. / Antonio Freitas Duarte; Luís Lopes da Costa. Springer International Publishing AG, 2020. p. 301-320.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

TY - CHAP

T1 - Leishmaniosis

T2 - new insights in a changing world

AU - Alexandre-pires, G.

AU - Santos, M.

AU - Rodrigues, M. A.

AU - Pereira, M. A.

AU - Gomes, J.

AU - Diaz, S. A.

AU - Gomes, L.

AU - Basso, A.

AU - Reisinho, A.

AU - Gomes, J.

AU - Leal, R.

AU - Correia, J.

AU - Bolas, A.

AU - Meireles, J.

AU - Santos-gomes, G.

AU - Pereira-da-fonseca, I.

PY - 2020/11/22

Y1 - 2020/11/22

N2 - Canine leishmaniosis caused by Leishmania infantum is a zoonotic disease of serious veterinary concern in the Mediterranean basin. In Portugal has been reported in dogs, cats and synanthropic rodents. Epidemiological changes and new hosts may contribute to increase zoonotic risk. A better knowledge on immune response, treatment and diagnosis are at the forefront of research on this disease. Host immune response is multifactorial, reflecting the organ specificity. Macrophages (MØ) are the definitive host cells, although neutrophils (PMN) are the first cells to encounter parasites soon after inoculation in the dermis. The PMN-parasite interaction decreases parasite viability, but PMN-MØ interaction induces nitric oxide production and release of neutrophil extracellular traps that contain parasites, controlling dog infection at early stages. Liver resident Kupffer cells (KC) efficiently phagocyte Leishmania by establishing an intimate contact with circulating blood. The impact of meglumine antimoniate (MG) over infected canine KC was investigated. The effect of different treatment protocols in dog’s immune response was assessed. MG+miltefosine treatments plus allopurinol restore lymphokine gene expression, pointing through a drug-induced reduction of anti-inflammatory and regulatory cytokines. Furthermore, increasing feline leishmaniosis and the inconsistent results of therapeutic protocols led the team to evaluate their safety and effectiveness in cat.

AB - Canine leishmaniosis caused by Leishmania infantum is a zoonotic disease of serious veterinary concern in the Mediterranean basin. In Portugal has been reported in dogs, cats and synanthropic rodents. Epidemiological changes and new hosts may contribute to increase zoonotic risk. A better knowledge on immune response, treatment and diagnosis are at the forefront of research on this disease. Host immune response is multifactorial, reflecting the organ specificity. Macrophages (MØ) are the definitive host cells, although neutrophils (PMN) are the first cells to encounter parasites soon after inoculation in the dermis. The PMN-parasite interaction decreases parasite viability, but PMN-MØ interaction induces nitric oxide production and release of neutrophil extracellular traps that contain parasites, controlling dog infection at early stages. Liver resident Kupffer cells (KC) efficiently phagocyte Leishmania by establishing an intimate contact with circulating blood. The impact of meglumine antimoniate (MG) over infected canine KC was investigated. The effect of different treatment protocols in dog’s immune response was assessed. MG+miltefosine treatments plus allopurinol restore lymphokine gene expression, pointing through a drug-induced reduction of anti-inflammatory and regulatory cytokines. Furthermore, increasing feline leishmaniosis and the inconsistent results of therapeutic protocols led the team to evaluate their safety and effectiveness in cat.

KW - Leishmania

KW - Leishmaniosis

KW - Host-immune-response

KW - Zoonosis

KW - Treatment

UR - http://link.springer.com/10.1007/978-3-030-61981-7_17

U2 - 10.1007/978-3-030-61981-7_17

DO - 10.1007/978-3-030-61981-7_17

M3 - Chapter

SN - 978-3-030-61980-0

SP - 301

EP - 320

BT - Advances in animal health, medicine and production

A2 - Freitas Duarte, Antonio

A2 - Lopes da Costa, Luís

PB - Springer International Publishing AG

ER -

Alexandre-pires G, Santos M, Rodrigues MA, Pereira MA, Gomes J, Diaz SA et al. Leishmaniosis: new insights in a changing world. In Freitas Duarte A, Lopes da Costa L, editors, Advances in animal health, medicine and production: a research portrait of the Centre for Interdisciplinary Research in Animal Health (CIISA), University of Lisbon, Portugal. Springer International Publishing AG. 2020. p. 301-320 doi: 10.1007/978-3-030-61981-7_17

Leishmaniosis: new insights in a changing world

Abstract

Keywords

UN SDGs

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