TY - JOUR
T1 - Lanthanide-Based Organic Salts
T2 - Synthesis, Characterization, and Cytotoxicity Studies
AU - Forte, Andreia
AU - Gago, Sandra
AU - Alves, Celso
AU - Silva, Joana
AU - Alves, Joana
AU - Pedrosa, Rui
AU - Laia, César A. T.
AU - Marrucho, Isabel M.
AU - Branco, Luís C.
N1 - info:eu-repo/grantAgreement/FCT/6820 - DCRRNI ID/PEst-C%2FEQB%2FLA0006%2F2013/PT#
info:eu-repo/grantAgreement/FCT/Concurso de Projectos de Investigação Científica e Desenvolvimento Tecnológico em todos os Domínios Científicos - 2010/PTDC%2FCTM-NAN%2F120658%2F2010/PT#
info:eu-repo/grantAgreement/FCT/OE/PD%2FBD%2F109625%2F2015/PT#
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04292%2F2020/PT#
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04292%2F2020/PT#
PY - 2023/10/18
Y1 - 2023/10/18
N2 - The formulation of magnetic ionic liquids (MILs) or organic salts based on lanthanides as anions has been explored. In this work, a set of choline-family-based salts, and two other, different cation families, were combined with Gadolinium(III) and Terbium(III) anions. Synthetic methodologies were previously optimized, and all organic salts were obtained as solids with melting temperatures higher than 100 °C. The magnetic moments obtained for the Gd(III) salts were, as expected, smaller than those obtained for the Tb(III)-based compounds. The values for Gd(III) and Tb(III) magnetic salts are in the range of 6.55–7.30 MB and 8.22–9.34 MB, respectively. It is important to note a correlation between the magnetic moments obtained for lanthanides, and the structural features of the cation. The cytotoxicity of lanthanide-based salts was also evaluated using 3T3, 293T, Caco2, and HepG2 cells, and it was revealed that most of the prepared compounds are not toxic.
AB - The formulation of magnetic ionic liquids (MILs) or organic salts based on lanthanides as anions has been explored. In this work, a set of choline-family-based salts, and two other, different cation families, were combined with Gadolinium(III) and Terbium(III) anions. Synthetic methodologies were previously optimized, and all organic salts were obtained as solids with melting temperatures higher than 100 °C. The magnetic moments obtained for the Gd(III) salts were, as expected, smaller than those obtained for the Tb(III)-based compounds. The values for Gd(III) and Tb(III) magnetic salts are in the range of 6.55–7.30 MB and 8.22–9.34 MB, respectively. It is important to note a correlation between the magnetic moments obtained for lanthanides, and the structural features of the cation. The cytotoxicity of lanthanide-based salts was also evaluated using 3T3, 293T, Caco2, and HepG2 cells, and it was revealed that most of the prepared compounds are not toxic.
KW - cytotoxicity
KW - gadolinium salts
KW - magnetic organic salts
KW - MRI contrast agents
KW - terbium salts
UR - http://www.scopus.com/inward/record.url?scp=85175024547&partnerID=8YFLogxK
U2 - 10.3390/molecules28207152
DO - 10.3390/molecules28207152
M3 - Article
C2 - 37894633
AN - SCOPUS:85175024547
SN - 1420-3049
VL - 28
JO - Molecules
JF - Molecules
IS - 20
M1 - 7152
ER -