Lanthanide-Based Organic Salts: Synthesis, Characterization, and Cytotoxicity Studies

Andreia Forte, Sandra Gago, Celso Alves, Joana Silva, Joana Alves, Rui Pedrosa, César A. T. Laia, Isabel M. Marrucho, Luís C. Branco

Research output: Contribution to journalArticlepeer-review

Abstract

The formulation of magnetic ionic liquids (MILs) or organic salts based on lanthanides as anions has been explored. In this work, a set of choline-family-based salts, and two other, different cation families, were combined with Gadolinium(III) and Terbium(III) anions. Synthetic methodologies were previously optimized, and all organic salts were obtained as solids with melting temperatures higher than 100 °C. The magnetic moments obtained for the Gd(III) salts were, as expected, smaller than those obtained for the Tb(III)-based compounds. The values for Gd(III) and Tb(III) magnetic salts are in the range of 6.55–7.30 MB and 8.22–9.34 MB, respectively. It is important to note a correlation between the magnetic moments obtained for lanthanides, and the structural features of the cation. The cytotoxicity of lanthanide-based salts was also evaluated using 3T3, 293T, Caco2, and HepG2 cells, and it was revealed that most of the prepared compounds are not toxic.
Original languageEnglish
Article number7152
Number of pages13
JournalMolecules
Volume28
Issue number20
DOIs
Publication statusPublished - 18 Oct 2023

Keywords

  • cytotoxicity
  • gadolinium salts
  • magnetic organic salts
  • MRI contrast agents
  • terbium salts

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