L2A5 Antibody or functional fragment thereof against tumour antigens

Paula Alexandra Quintela Videira (Inventor), Carlos Manuel Mendes Novo (Inventor), Liliana Raquel Rodrigues Loureiro (Inventor), Mylène Adelaide do Rosário Carrascal (Inventor), José Alexandre Ribeiro de Castro Ferreira (Inventor), Maria Angelina de Sá Palma (Inventor), Lúcio Lara Santos (Inventor), Luís Carlos Oliveira Lima (Inventor), Wengang Chai (Inventor), Michael Philippe Bachmann (Inventor)

Research output: PatentRegional/Other National Application


This invention provides an antibody or functional antibody fragments, or probe thereof directed against a unique group of antigens identified in cancer. The present invention comprises nucleotide sequences derived from L2A5 monoclonal antibody. The antibody or functional antibody fragment, or probe thereof includes a variable heavy chain domain and a variable light chain domain that has an amino acid sequence provided herein. This DNA/ amino acid sequence conjugation is unique and has never been described before. The present invention further provides antibody or functional antibody fragment or a conjugate or a recombinant protein useful in the detection, treatment and prevention of human disease, including cancer.
Original languageEnglish
Patent numberEP3743726
IPCG01N 33/ 574 A I
Priority date26/01/18
Filing date26/08/20
Publication statusPublished - 2 Dec 2020


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