Kinetics of cytokine expression in mice with invasive aspergillosis: Lethal infection and protection

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Abstract

Aspergillus fumigatus causes lethal invasive aspergillosis in cortisone-treated mice while immunized mice are protected. Kinetics of interferon (IFN)-γ, tumor necrosis factor-α, interleukin (IL)-12p40, IL-4 and IL-10 expression were assessed by reverse transcription-PCR in the spleen and lungs of mice. After immunization, mice were protected from otherwise lethal infection, with concomitant high expression levels of IFN-γ early in the lungs and later in the spleen. In the lethal infection model cortisone-treated infected mice presented high expression levels of IL-10 in the spleen and in the lungs. Immunocompetent mice were able to control the disease and presented earlier expression of IL-12p40 and IFN-γ in lungs and spleen. These results confirm the importance of Th1 dependent immunity against invasive aspergillosis.

Original languageEnglish
Pages (from-to)167-173
Number of pages7
JournalFems Immunology And Medical Microbiology
Volume32
Issue number2
DOIs
Publication statusPublished - 14 Jan 2002

Keywords

  • Aspergillus fumigatus
  • Reverse transcription-PCR
  • Th1/Th2 cytokine

UN Sustainable Development Goals (SDGs)

  • SDG 3 - Good Health and Well-Being

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