JC polyomavirus nephropathy confirmed by using an in-house polymerase chain reaction method

S. Querido; C. Jorge; H. Sousa; R. Birne; P. Matias; A. Weigert; T. Adragão; M. Bruges; S. Ramos; M. Santos; P. Paixão; M. D. Curran; D. Machado

doi:10.1111/tid.12426

JC polyomavirus nephropathy confirmed by using an in-house polymerase chain reaction method

S. Querido, C. Jorge, H. Sousa, R. Birne, P. Matias, A. Weigert, T. Adragão, M. Bruges, S. Ramos, M. Santos, P. Paixão, M. D. Curran, D. Machado

NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

We report the case of an isolated JC virus (JCV) infection, without co-infection by polyoma BK virus (BKV), associated with nephropathy 4 years after kidney transplantation. Clinical suspicion followed the observation of a decrease in estimated glomerular filtration rate (eGFR) and a renal allograft biopsy revealing polyomavirus-associated tubulointerstitial nephritis and positivity for SV40. An in-house real-time polymerase chain reaction assay, targeting the presence of JCV and the absence of BKV in biopsy tissue, confirmed diagnosis. Thirteen months after diagnosis, and following therapeutic measures, eGFR remains stable.

Original language	English
Pages (from-to)	732-736
Number of pages	5
Journal	Transplant Infectious Disease
Volume	17
Issue number	5
DOIs	https://doi.org/10.1111/tid.12426
Publication status	Published - 1 Jan 2015

Keywords

JC virus
Nephropathy
PCR
PVAN
Renal transplant
Viremia
Viruria

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/tid.12426

Cite this

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title = "JC polyomavirus nephropathy confirmed by using an in-house polymerase chain reaction method",

abstract = "We report the case of an isolated JC virus (JCV) infection, without co-infection by polyoma BK virus (BKV), associated with nephropathy 4 years after kidney transplantation. Clinical suspicion followed the observation of a decrease in estimated glomerular filtration rate (eGFR) and a renal allograft biopsy revealing polyomavirus-associated tubulointerstitial nephritis and positivity for SV40. An in-house real-time polymerase chain reaction assay, targeting the presence of JCV and the absence of BKV in biopsy tissue, confirmed diagnosis. Thirteen months after diagnosis, and following therapeutic measures, eGFR remains stable.",

keywords = "JC virus, Nephropathy, PCR, PVAN, Renal transplant, Viremia, Viruria",

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T1 - JC polyomavirus nephropathy confirmed by using an in-house polymerase chain reaction method

AU - Querido, S.

AU - Jorge, C.

AU - Sousa, H.

AU - Birne, R.

AU - Matias, P.

AU - Weigert, A.

AU - Adragão, T.

AU - Bruges, M.

AU - Ramos, S.

AU - Santos, M.

AU - Paixão, P.

AU - Curran, M. D.

AU - Machado, D.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - We report the case of an isolated JC virus (JCV) infection, without co-infection by polyoma BK virus (BKV), associated with nephropathy 4 years after kidney transplantation. Clinical suspicion followed the observation of a decrease in estimated glomerular filtration rate (eGFR) and a renal allograft biopsy revealing polyomavirus-associated tubulointerstitial nephritis and positivity for SV40. An in-house real-time polymerase chain reaction assay, targeting the presence of JCV and the absence of BKV in biopsy tissue, confirmed diagnosis. Thirteen months after diagnosis, and following therapeutic measures, eGFR remains stable.

AB - We report the case of an isolated JC virus (JCV) infection, without co-infection by polyoma BK virus (BKV), associated with nephropathy 4 years after kidney transplantation. Clinical suspicion followed the observation of a decrease in estimated glomerular filtration rate (eGFR) and a renal allograft biopsy revealing polyomavirus-associated tubulointerstitial nephritis and positivity for SV40. An in-house real-time polymerase chain reaction assay, targeting the presence of JCV and the absence of BKV in biopsy tissue, confirmed diagnosis. Thirteen months after diagnosis, and following therapeutic measures, eGFR remains stable.

KW - JC virus

KW - Nephropathy

KW - PCR

KW - PVAN

KW - Renal transplant

KW - Viremia

KW - Viruria

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U2 - 10.1111/tid.12426

DO - 10.1111/tid.12426

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SN - 1398-2273

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SP - 732

EP - 736

JO - Transplant Infectious Disease

JF - Transplant Infectious Disease

IS - 5

ER -

JC polyomavirus nephropathy confirmed by using an in-house polymerase chain reaction method

Abstract

Keywords

UN SDGs

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