Iron-Sulfur Centers: New Roles for Ancient Metal Sites

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9 Citations (Scopus)


Iron-sulfur clusters are ubiquitous and ancient prosthetic groups that are present in all kingdoms of life. They are flexible in terms of coordination and redox properties. The first function of these proteins to be identified was electron transfer back in the 1960s, but since then other functions have been discovered. Iron-sulfur centers are directly involved in catalysis, as sensors of gases (nitric oxide and oxygen), iron, and other cellular compounds, and also participate in biosynthetic pathways of iron-sulfur clusters from the basic to the more complex ones. The role of iron-sulfur clusters is emerging in DNA repair, as the driving force for DNA lesion recognition. In recent years, more and more enzymes containing iron-sulfur clusters have been identified, and it is now known that these centers catalyze a wide range of diverse reactions.

Original languageEnglish
Title of host publicationComprehensive Inorganic Chemistry II
Subtitle of host publicationFrom Elements to Applications
Number of pages46
ISBN (Print)978-008096529-1
Publication statusPublished - Aug 2013


  • (Bio)electrochemistry
  • Biocatalysis
  • Bioinorganic
  • Biophysics
  • Biosynthesis of iron-sulfur centers
  • Catalytic iron-sulfur centers
  • DNA repair
  • Electron transfer
  • Energy bioconversion (hydrogen)
  • Hydrogenase
  • Inorganic systems as models for biocatalysis
  • Iron homeostasis
  • Iron-sulfur centers
  • Nitrogenase
  • Nonredox catalysis
  • Protein-protein interactions
  • Role of metals in biology
  • SAM-dependent enzyme
  • Spectroscopy (NMR, EPR, and Mössbauer)
  • Transcription regulators


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