Iron oxide nanoparticles stabilized with a bilayer of oleic acid for magnetic hyperthermia and MRI applications

Paula I P Soares, César A T Laia, Alexandra Carvalho, Laura C J Pereira, Joana T. Coutinho, Isabel M M Ferreira, Carlos M M Novo, João Paulo Borges

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Iron oxide nanoparticles (Fe3O4, IONPs) are promising candidates for several biomedical applications such as magnetic hyperthermia and as contrast agents for magnetic resonance imaging (MRI). However, their colloidal stability in physiological conditions hinders their application requiring the use of biocompatible surfactant agents. The present investigation focuses on obtaining highly stable IONPs, stabilized by the presence of an oleic acid bilayer. Critical aspects such as oleic acid concentration and pH were optimized to ensure maximum stability. NPs composed of an iron oxide core with an average diameter of 9 nm measured using transmission electron microscopy (TEM) form agglomerates with an hydrodynamic diameter of around 170 nm when dispersed in water in the presence of an oleic acid bilayer, remaining stable (zeta potential of -120 mV). Magnetic hyperthermia and the relaxivities measurements show high efficiency at neutral pH which enables their use for both magnetic hyperthermia and MRI.

Original languageEnglish
Pages (from-to)240-247
Number of pages8
JournalApplied Surface Science
Volume383
DOIs
Publication statusPublished - 15 Oct 2016

Keywords

  • Iron oxide nanoparticles
  • Magnetic hyperthermia
  • Magnetic resonance imaging
  • Oleic acid

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