TY - JOUR
T1 - Intestinal Alkaline Phosphatase
T2 - A Review of This Enzyme Role in the Intestinal Barrier Function
AU - Santos, Gilberto Maia
AU - Ismael, Shámila
AU - Morais, Juliana
AU - Araújo, João R.
AU - Faria, Ana
AU - Calhau, Conceição
AU - Marques, Cláudia
N1 - Funding Information:
This study was supported by ERDF through the operation POCI-01-0145-ERDF-007746 funded by Programa Operacional Competitividade e Internacionaliza??o?COMPETE2020 and by National Funds through FCT?Funda??o para a Ci?ncia e a Tecnologia within CINTESIS, R&D Unit (reference UID/IC/4255/2013) and (PTDC/BAA-AGR/7419/2020).
PY - 2022/3/30
Y1 - 2022/3/30
N2 - Intestinal alkaline phosphatase (IALP) has recently assumed a special relevance, being the subject of study in the prevention and treatment of certain diseases related to leaky gut. This brush border enzyme (ecto-enzyme) plays an important role in the maintenance of intestinal microbial homeostasis and intestinal barrier function through its ability to dephosphorylate lipopolysaccharide (LPS). This review addresses how IALP and intestinal barrier dysfunction may be implicated in the pathophysiology of specific diseases such as inflammatory bowel disease, necrotizing enterocolitis, and metabolic syndrome. The use of IALP as a possible biomarker to assess intestinal barrier function and strategies to modulate IALP activity are also discussed.
AB - Intestinal alkaline phosphatase (IALP) has recently assumed a special relevance, being the subject of study in the prevention and treatment of certain diseases related to leaky gut. This brush border enzyme (ecto-enzyme) plays an important role in the maintenance of intestinal microbial homeostasis and intestinal barrier function through its ability to dephosphorylate lipopolysaccharide (LPS). This review addresses how IALP and intestinal barrier dysfunction may be implicated in the pathophysiology of specific diseases such as inflammatory bowel disease, necrotizing enterocolitis, and metabolic syndrome. The use of IALP as a possible biomarker to assess intestinal barrier function and strategies to modulate IALP activity are also discussed.
KW - inflammatory bowel disease
KW - intestinal alkaline phosphatase
KW - intestinal barrier function
KW - low-grade chronic inflammation
KW - metabolic dysfunction
KW - necrotizing enterocolitis
KW - obesity
UR - http://www.scopus.com/inward/record.url?scp=85127426722&partnerID=8YFLogxK
U2 - 10.3390/microorganisms10040746
DO - 10.3390/microorganisms10040746
M3 - Review article
C2 - 35456797
AN - SCOPUS:85127426722
SN - 2076-2607
VL - 10
JO - Microorganisms
JF - Microorganisms
IS - 4
M1 - 746
ER -