TY - JOUR
T1 - Interventions for age-related diseases
T2 - Shifting the paradigm
AU - Figueira, Inês
AU - Mladenovic Djordjevic, Aleksandra
AU - Fernandes, Adelaide
AU - Lopez-Contreras, Andres
AU - Henriques, Catarina M.
AU - Selman, Colin
AU - Ferreiro, Elisabete
AU - Gonos, Efstathios S.
AU - Trejo, José Luis
AU - Misra, Juhi
AU - Rasmussen, Lene Juel
AU - Xapelli, Sara
AU - Ellam, Timothy
AU - Bellantuono, Ilaria
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Over 60% of people aged over 65 are affected by multiple morbidities, which are more difficult to treat, generate increased healthcare costs and lead to poor quality of life compared to individual diseases. With the number of older people steadily increasing this presents a societal challenge. Age is the major risk factor for age-related diseases and recent research developments have led to the proposal that pharmacological interventions targeting common mechanisms of ageing may be able to delay the onset of multimorbidity. Here we review the state of the knowledge of multimorbidity, appraise the available evidence supporting the role of mechanisms of ageing in the development of the most common age-related diseases and assess potential molecules that may successfully target those key mechanisms.
AB - Over 60% of people aged over 65 are affected by multiple morbidities, which are more difficult to treat, generate increased healthcare costs and lead to poor quality of life compared to individual diseases. With the number of older people steadily increasing this presents a societal challenge. Age is the major risk factor for age-related diseases and recent research developments have led to the proposal that pharmacological interventions targeting common mechanisms of ageing may be able to delay the onset of multimorbidity. Here we review the state of the knowledge of multimorbidity, appraise the available evidence supporting the role of mechanisms of ageing in the development of the most common age-related diseases and assess potential molecules that may successfully target those key mechanisms.
KW - Ageing
KW - Chronic diseases
KW - Geroprotectors
KW - Geroscience
KW - Multimorbidity
UR - http://www.scopus.com/inward/record.url?scp=84999035290&partnerID=8YFLogxK
U2 - 10.1016/j.mad.2016.09.009
DO - 10.1016/j.mad.2016.09.009
M3 - Review article
C2 - 27693441
AN - SCOPUS:84999035290
SN - 0047-6374
VL - 160
SP - 69
EP - 92
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
ER -