Abstract
This article reviews the importance of the round-window membrane in exposing the labyrinth to or protecting it from the toxic effects of otitis media. Characteristics of the immune system in the human middle ear and middle-ear mechanisms against bacteria are explained. The role of bacteria and bacterial products in inner-ear damage is detailed, and related pathological events are described. The hypothetical role of inflammatory mediators in bacteria-induced inner-ear toxicity is particularly emphasized. Clinical conditions causing these events are detailed, and the most frequently involved microorganisms are mentioned. Finally, round-window membrane macroscopic and microscopic anatomy is discussed, and considerations about the exact role of membrane inflammation--protection versus damage of the inner ear--are expressed.
Original language | English |
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Pages (from-to) | 87-91 |
Number of pages | 5 |
Journal | The international tinnitus journal |
Volume | 9 |
Issue number | 2 |
Publication status | Published - 2003 |
Keywords
- Bacterial Toxins
- Ear, Inner
- Ear, Middle
- Humans
- Otitis Media
- Permeability
- Round Window, Ear
- Journal Article
- Review