Intensive care unit patients with lower respiratory tract nosocomial infections: the ENIRRIs project

Gennaro De Pascale, Otavio T Ranzani, Saad Nseir, Jean Chastre, Tobias Welte, Massimo Antonelli, Paolo Navalesi, Eugenio Garofalo, Andrea Bruni, Luis Miguel Coelho, Szymon Skoczynski, Federico Longhini, Fabio Silvio Taccone, David Grimaldi, Helmut J F Salzer, Christoph Lange, Filipe Froes, Antoni Artigas, Emili Díaz, Jordi Vallés & 30 others Alejandro Rodríguez, Mauro Panigada, Vittoria Comellini, Luca Fasano, Paolo M Soave, Giorgia Spinazzola, Charles-Edouard Luyt, Francisco Alvarez-Lerma, Judith Marin, Joan Ramon Masclans, Davide Chiumello, Angelo Pezzi, Marcus Schultz, Hafiz Mohamed, Menno Van Der Eerden, Roger A S Hoek, D A M P J Gommers, Marta Di Pasquale, Rok Civljak, Marko Kutleša, Matteo Bassetti, George Dimopoulos, Stefano Nava, Fernando Rios, Fernando G Zampieri, Pedro Povoa, Lieuwe D Bos, Stefano Aliberti, Antoni Torres, Ignacio Martín-Loeches

Research output: Contribution to journalArticle

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Abstract

The clinical course of intensive care unit (ICU) patients may be complicated by a large spectrum of lower respiratory tract infections (LRTI), defined by specific epidemiological, clinical and microbiological aspects. A European network for ICU-related respiratory infections (ENIRRIs), supported by the European Respiratory Society, has been recently established, with the aim at studying all respiratory tract infective episodes except community-acquired ones. A multicentre, observational study is in progress, enrolling more than 1000 patients fulfilling the clinical, biochemical and radiological findings consistent with a LRTI. This article describes the methodology of this study. A specific interest is the clinical impact of non-ICU-acquired nosocomial pneumonia requiring ICU admission, non-ventilator-associated LRTIs occurring in the ICU, and ventilator-associated tracheobronchitis. The clinical meaning of microbiologically negative infectious episodes and specific details on antibiotic administration modalities, dosages and duration are also highlighted. Recently released guidelines address many unresolved questions which might be answered by such large-scale observational investigations. In light of the paucity of data regarding such topics, new interesting information is expected to be obtained from our network research activities, contributing to optimisation of care for critically ill patients in the ICU.

Original languageEnglish
Article number00092-2017
Pages (from-to)Online
Number of pages5
JournalBMJ Open
Volume3
Issue number4
DOIs
Publication statusPublished - Oct 2017

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Cross Infection
Respiratory Tract Infections
Intensive Care Units
Mechanical Ventilators
Critical Illness
Respiratory System
Multicenter Studies
Observational Studies
Pneumonia
Guidelines
Anti-Bacterial Agents
Research

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De Pascale, G., Ranzani, O. T., Nseir, S., Chastre, J., Welte, T., Antonelli, M., ... Martín-Loeches, I. (2017). Intensive care unit patients with lower respiratory tract nosocomial infections: the ENIRRIs project. BMJ Open, 3(4), Online. [00092-2017]. https://doi.org/10.1183/23120541.00092-2017
De Pascale, Gennaro ; Ranzani, Otavio T ; Nseir, Saad ; Chastre, Jean ; Welte, Tobias ; Antonelli, Massimo ; Navalesi, Paolo ; Garofalo, Eugenio ; Bruni, Andrea ; Coelho, Luis Miguel ; Skoczynski, Szymon ; Longhini, Federico ; Taccone, Fabio Silvio ; Grimaldi, David ; Salzer, Helmut J F ; Lange, Christoph ; Froes, Filipe ; Artigas, Antoni ; Díaz, Emili ; Vallés, Jordi ; Rodríguez, Alejandro ; Panigada, Mauro ; Comellini, Vittoria ; Fasano, Luca ; Soave, Paolo M ; Spinazzola, Giorgia ; Luyt, Charles-Edouard ; Alvarez-Lerma, Francisco ; Marin, Judith ; Masclans, Joan Ramon ; Chiumello, Davide ; Pezzi, Angelo ; Schultz, Marcus ; Mohamed, Hafiz ; Van Der Eerden, Menno ; Hoek, Roger A S ; Gommers, D A M P J ; Pasquale, Marta Di ; Civljak, Rok ; Kutleša, Marko ; Bassetti, Matteo ; Dimopoulos, George ; Nava, Stefano ; Rios, Fernando ; Zampieri, Fernando G ; Povoa, Pedro ; Bos, Lieuwe D ; Aliberti, Stefano ; Torres, Antoni ; Martín-Loeches, Ignacio. / Intensive care unit patients with lower respiratory tract nosocomial infections: the ENIRRIs project. In: BMJ Open. 2017 ; Vol. 3, No. 4. pp. Online.
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abstract = "The clinical course of intensive care unit (ICU) patients may be complicated by a large spectrum of lower respiratory tract infections (LRTI), defined by specific epidemiological, clinical and microbiological aspects. A European network for ICU-related respiratory infections (ENIRRIs), supported by the European Respiratory Society, has been recently established, with the aim at studying all respiratory tract infective episodes except community-acquired ones. A multicentre, observational study is in progress, enrolling more than 1000 patients fulfilling the clinical, biochemical and radiological findings consistent with a LRTI. This article describes the methodology of this study. A specific interest is the clinical impact of non-ICU-acquired nosocomial pneumonia requiring ICU admission, non-ventilator-associated LRTIs occurring in the ICU, and ventilator-associated tracheobronchitis. The clinical meaning of microbiologically negative infectious episodes and specific details on antibiotic administration modalities, dosages and duration are also highlighted. Recently released guidelines address many unresolved questions which might be answered by such large-scale observational investigations. In light of the paucity of data regarding such topics, new interesting information is expected to be obtained from our network research activities, contributing to optimisation of care for critically ill patients in the ICU.",
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De Pascale, G, Ranzani, OT, Nseir, S, Chastre, J, Welte, T, Antonelli, M, Navalesi, P, Garofalo, E, Bruni, A, Coelho, LM, Skoczynski, S, Longhini, F, Taccone, FS, Grimaldi, D, Salzer, HJF, Lange, C, Froes, F, Artigas, A, Díaz, E, Vallés, J, Rodríguez, A, Panigada, M, Comellini, V, Fasano, L, Soave, PM, Spinazzola, G, Luyt, C-E, Alvarez-Lerma, F, Marin, J, Masclans, JR, Chiumello, D, Pezzi, A, Schultz, M, Mohamed, H, Van Der Eerden, M, Hoek, RAS, Gommers, DAMPJ, Pasquale, MD, Civljak, R, Kutleša, M, Bassetti, M, Dimopoulos, G, Nava, S, Rios, F, Zampieri, FG, Povoa, P, Bos, LD, Aliberti, S, Torres, A & Martín-Loeches, I 2017, 'Intensive care unit patients with lower respiratory tract nosocomial infections: the ENIRRIs project', BMJ Open, vol. 3, no. 4, 00092-2017, pp. Online. https://doi.org/10.1183/23120541.00092-2017

Intensive care unit patients with lower respiratory tract nosocomial infections: the ENIRRIs project. / De Pascale, Gennaro; Ranzani, Otavio T; Nseir, Saad; Chastre, Jean; Welte, Tobias; Antonelli, Massimo; Navalesi, Paolo; Garofalo, Eugenio; Bruni, Andrea; Coelho, Luis Miguel; Skoczynski, Szymon; Longhini, Federico; Taccone, Fabio Silvio; Grimaldi, David; Salzer, Helmut J F; Lange, Christoph; Froes, Filipe; Artigas, Antoni; Díaz, Emili; Vallés, Jordi; Rodríguez, Alejandro; Panigada, Mauro; Comellini, Vittoria; Fasano, Luca; Soave, Paolo M; Spinazzola, Giorgia; Luyt, Charles-Edouard; Alvarez-Lerma, Francisco; Marin, Judith; Masclans, Joan Ramon; Chiumello, Davide; Pezzi, Angelo; Schultz, Marcus; Mohamed, Hafiz; Van Der Eerden, Menno; Hoek, Roger A S; Gommers, D A M P J; Pasquale, Marta Di; Civljak, Rok; Kutleša, Marko; Bassetti, Matteo; Dimopoulos, George; Nava, Stefano; Rios, Fernando; Zampieri, Fernando G; Povoa, Pedro; Bos, Lieuwe D; Aliberti, Stefano; Torres, Antoni; Martín-Loeches, Ignacio.

In: BMJ Open, Vol. 3, No. 4, 00092-2017, 10.2017, p. Online.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Intensive care unit patients with lower respiratory tract nosocomial infections: the ENIRRIs project

AU - De Pascale, Gennaro

AU - Ranzani, Otavio T

AU - Nseir, Saad

AU - Chastre, Jean

AU - Welte, Tobias

AU - Antonelli, Massimo

AU - Navalesi, Paolo

AU - Garofalo, Eugenio

AU - Bruni, Andrea

AU - Coelho, Luis Miguel

AU - Skoczynski, Szymon

AU - Longhini, Federico

AU - Taccone, Fabio Silvio

AU - Grimaldi, David

AU - Salzer, Helmut J F

AU - Lange, Christoph

AU - Froes, Filipe

AU - Artigas, Antoni

AU - Díaz, Emili

AU - Vallés, Jordi

AU - Rodríguez, Alejandro

AU - Panigada, Mauro

AU - Comellini, Vittoria

AU - Fasano, Luca

AU - Soave, Paolo M

AU - Spinazzola, Giorgia

AU - Luyt, Charles-Edouard

AU - Alvarez-Lerma, Francisco

AU - Marin, Judith

AU - Masclans, Joan Ramon

AU - Chiumello, Davide

AU - Pezzi, Angelo

AU - Schultz, Marcus

AU - Mohamed, Hafiz

AU - Van Der Eerden, Menno

AU - Hoek, Roger A S

AU - Gommers, D A M P J

AU - Pasquale, Marta Di

AU - Civljak, Rok

AU - Kutleša, Marko

AU - Bassetti, Matteo

AU - Dimopoulos, George

AU - Nava, Stefano

AU - Rios, Fernando

AU - Zampieri, Fernando G

AU - Povoa, Pedro

AU - Bos, Lieuwe D

AU - Aliberti, Stefano

AU - Torres, Antoni

AU - Martín-Loeches, Ignacio

PY - 2017/10

Y1 - 2017/10

N2 - The clinical course of intensive care unit (ICU) patients may be complicated by a large spectrum of lower respiratory tract infections (LRTI), defined by specific epidemiological, clinical and microbiological aspects. A European network for ICU-related respiratory infections (ENIRRIs), supported by the European Respiratory Society, has been recently established, with the aim at studying all respiratory tract infective episodes except community-acquired ones. A multicentre, observational study is in progress, enrolling more than 1000 patients fulfilling the clinical, biochemical and radiological findings consistent with a LRTI. This article describes the methodology of this study. A specific interest is the clinical impact of non-ICU-acquired nosocomial pneumonia requiring ICU admission, non-ventilator-associated LRTIs occurring in the ICU, and ventilator-associated tracheobronchitis. The clinical meaning of microbiologically negative infectious episodes and specific details on antibiotic administration modalities, dosages and duration are also highlighted. Recently released guidelines address many unresolved questions which might be answered by such large-scale observational investigations. In light of the paucity of data regarding such topics, new interesting information is expected to be obtained from our network research activities, contributing to optimisation of care for critically ill patients in the ICU.

AB - The clinical course of intensive care unit (ICU) patients may be complicated by a large spectrum of lower respiratory tract infections (LRTI), defined by specific epidemiological, clinical and microbiological aspects. A European network for ICU-related respiratory infections (ENIRRIs), supported by the European Respiratory Society, has been recently established, with the aim at studying all respiratory tract infective episodes except community-acquired ones. A multicentre, observational study is in progress, enrolling more than 1000 patients fulfilling the clinical, biochemical and radiological findings consistent with a LRTI. This article describes the methodology of this study. A specific interest is the clinical impact of non-ICU-acquired nosocomial pneumonia requiring ICU admission, non-ventilator-associated LRTIs occurring in the ICU, and ventilator-associated tracheobronchitis. The clinical meaning of microbiologically negative infectious episodes and specific details on antibiotic administration modalities, dosages and duration are also highlighted. Recently released guidelines address many unresolved questions which might be answered by such large-scale observational investigations. In light of the paucity of data regarding such topics, new interesting information is expected to be obtained from our network research activities, contributing to optimisation of care for critically ill patients in the ICU.

U2 - 10.1183/23120541.00092-2017

DO - 10.1183/23120541.00092-2017

M3 - Article

VL - 3

SP - Online

JO - RMD Open

JF - RMD Open

SN - 2044-6055

IS - 4

M1 - 00092-2017

ER -

De Pascale G, Ranzani OT, Nseir S, Chastre J, Welte T, Antonelli M et al. Intensive care unit patients with lower respiratory tract nosocomial infections: the ENIRRIs project. BMJ Open. 2017 Oct;3(4):Online. 00092-2017. https://doi.org/10.1183/23120541.00092-2017