Insulin Action in Peripheral Glucose Uptake - The Molecular Perspective: Acção Periférica da Insulina na Captação de Glucose – a Perspectiva Molecular

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Abstract

In the recent years, insulin resistance has become the aim of numerous studies and one of the major focuses for pharmacological research and intervention. As a logical consequence, important steps towards the knowledge of insulin action and its alterations have been added at a high rate. Therefore, the awareness about the recent breakthroughs in this field and about how they fit within the whole picture of insulin action seems to be very useful, both in clinical and research practice.
The present article is the first of two mini-reviews concerning peripheral insulin action in glucose uptake. This first review article aims at the intracellular events leading to insulin-dependent glucose uptake, whereas in the second review insulin action will be approached in a whole-body perspective, giving particular emphasis to differences in insulin action according to the prandial state.
Thus, in the present review, we will provide a brief overview of the major insulin signaling pathways involved in peripheral (extra-hepatic) glucose uptake. Although this article does not aim pharmacological therapeutic, we hope that it may launch some minimum comprehensive basis to better understand the mechanism behind the pathophysiology and pharmacology of insulin action.
Original languageEnglish
Pages (from-to)87
Number of pages9
JournalRevista Portuguesa de Endocrinologia, Diabetes e Metabolismo
Volume6
Issue number1
Publication statusPublished - 2011

Keywords

  • Insulin
  • Insulin action
  • Insulin receptor
  • insulin signalling pathway
  • glucose uptake

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