Insulin Action in Peripheral Glucose Uptake - The Molecular Perspective

Acção Periférica da Insulina na Captação de Glucose – a Perspectiva Molecular

Research output: Contribution to journalReview article

7 Downloads (Pure)

Abstract

In the recent years, insulin resistance has become the aim of numerous studies and one of the major focuses for pharmacological research and intervention. As a logical consequence, important steps towards the knowledge of insulin action and its alterations have been added at a high rate. Therefore, the awareness about the recent breakthroughs in this field and about how they fit within the whole picture of insulin action seems to be very useful, both in clinical and research practice.
The present article is the first of two mini-reviews concerning peripheral insulin action in glucose uptake. This first review article aims at the intracellular events leading to insulin-dependent glucose uptake, whereas in the second review insulin action will be approached in a whole-body perspective, giving particular emphasis to differences in insulin action according to the prandial state.
Thus, in the present review, we will provide a brief overview of the major insulin signaling pathways involved in peripheral (extra-hepatic) glucose uptake. Although this article does not aim pharmacological therapeutic, we hope that it may launch some minimum comprehensive basis to better understand the mechanism behind the pathophysiology and pharmacology of insulin action.
Original languageEnglish
Pages (from-to)87
Number of pages9
JournalRevista Portuguesa de Endocrinologia, Diabetes e Metabolismo
Volume6
Issue number1
Publication statusPublished - 2011

Fingerprint

Insulin
Glucose
Pharmacology
Research
Meals
Insulin Resistance
Liver

Keywords

  • Insulin
  • Insulin action
  • Insulin receptor
  • insulin signalling pathway
  • glucose uptake

Cite this

@article{7443a57a1fd449cc867bd1421210daac,
title = "Insulin Action in Peripheral Glucose Uptake - The Molecular Perspective: Ac{\cc}{\~a}o Perif{\'e}rica da Insulina na Capta{\cc}{\~a}o de Glucose – a Perspectiva Molecular",
abstract = "In the recent years, insulin resistance has become the aim of numerous studies and one of the major focuses for pharmacological research and intervention. As a logical consequence, important steps towards the knowledge of insulin action and its alterations have been added at a high rate. Therefore, the awareness about the recent breakthroughs in this field and about how they fit within the whole picture of insulin action seems to be very useful, both in clinical and research practice. The present article is the first of two mini-reviews concerning peripheral insulin action in glucose uptake. This first review article aims at the intracellular events leading to insulin-dependent glucose uptake, whereas in the second review insulin action will be approached in a whole-body perspective, giving particular emphasis to differences in insulin action according to the prandial state. Thus, in the present review, we will provide a brief overview of the major insulin signaling pathways involved in peripheral (extra-hepatic) glucose uptake. Although this article does not aim pharmacological therapeutic, we hope that it may launch some minimum comprehensive basis to better understand the mechanism behind the pathophysiology and pharmacology of insulin action.",
keywords = "Insulin, Insulin action, Insulin receptor, insulin signalling pathway, glucose uptake",
author = "Afonso, {Ricardo A.}",
year = "2011",
language = "English",
volume = "6",
pages = "87",
journal = "Revista Portuguesa de Endocrinologia, Diabetes e Metabolismo",
issn = "1646-3439",
number = "1",

}

TY - JOUR

T1 - Insulin Action in Peripheral Glucose Uptake - The Molecular Perspective

T2 - Acção Periférica da Insulina na Captação de Glucose – a Perspectiva Molecular

AU - Afonso, Ricardo A.

PY - 2011

Y1 - 2011

N2 - In the recent years, insulin resistance has become the aim of numerous studies and one of the major focuses for pharmacological research and intervention. As a logical consequence, important steps towards the knowledge of insulin action and its alterations have been added at a high rate. Therefore, the awareness about the recent breakthroughs in this field and about how they fit within the whole picture of insulin action seems to be very useful, both in clinical and research practice. The present article is the first of two mini-reviews concerning peripheral insulin action in glucose uptake. This first review article aims at the intracellular events leading to insulin-dependent glucose uptake, whereas in the second review insulin action will be approached in a whole-body perspective, giving particular emphasis to differences in insulin action according to the prandial state. Thus, in the present review, we will provide a brief overview of the major insulin signaling pathways involved in peripheral (extra-hepatic) glucose uptake. Although this article does not aim pharmacological therapeutic, we hope that it may launch some minimum comprehensive basis to better understand the mechanism behind the pathophysiology and pharmacology of insulin action.

AB - In the recent years, insulin resistance has become the aim of numerous studies and one of the major focuses for pharmacological research and intervention. As a logical consequence, important steps towards the knowledge of insulin action and its alterations have been added at a high rate. Therefore, the awareness about the recent breakthroughs in this field and about how they fit within the whole picture of insulin action seems to be very useful, both in clinical and research practice. The present article is the first of two mini-reviews concerning peripheral insulin action in glucose uptake. This first review article aims at the intracellular events leading to insulin-dependent glucose uptake, whereas in the second review insulin action will be approached in a whole-body perspective, giving particular emphasis to differences in insulin action according to the prandial state. Thus, in the present review, we will provide a brief overview of the major insulin signaling pathways involved in peripheral (extra-hepatic) glucose uptake. Although this article does not aim pharmacological therapeutic, we hope that it may launch some minimum comprehensive basis to better understand the mechanism behind the pathophysiology and pharmacology of insulin action.

KW - Insulin

KW - Insulin action

KW - Insulin receptor

KW - insulin signalling pathway

KW - glucose uptake

M3 - Review article

VL - 6

SP - 87

JO - Revista Portuguesa de Endocrinologia, Diabetes e Metabolismo

JF - Revista Portuguesa de Endocrinologia, Diabetes e Metabolismo

SN - 1646-3439

IS - 1

ER -