Insights on the Mycobacterium tuberculosis population structure associated with migrants from Portuguese-speaking countries over a three-year period in Greater Lisbon, Portugal:

Implications at the public health level

Catarina Pereira, Pedro Gomes, Ricardo Taveira, Carla Silva, Fernando Maltez, Rita Macedo, Catarina Costa, David Couvin, Nalin Rastogi, Miguel Viveiros, João Perdigão, Isabel Portugal

Research output: Contribution to journalArticle

Abstract

Tuberculosis among foreign-born patients is a key indicator of country-level epidemiological profiles and, of an increasing concern in Europe given the more intensified migratory waves of refugees. Since Portugal presents a lower immigrant-associated TB incidence rate when compared to other European countries, we sought to characterize the epidemiology and transmission dynamics among the foreign-born population coming from Portuguese-speaking countries that are associated with higher TB incidences. In the present study we analyzed 133 Mycobacterium tuberculosis isolates obtained from foreign-born individuals over a three-year period in Lisbon, Portugal, using molecular epidemiological methods such as spoligotyping and 24-loci MIRU-VNTR. Moreover, all strains were subjected to drug susceptibility testing. The genetic profiles obtained suggest that strain importation from Portuguese speaking countries plays a less important role in TB epidemiology but instead argue in favor of a high degree of penetrance of Portuguese endemic strains to the migrant population, including multidrug resistant strains, which is particularly relevant to active screening programs.

Original languageEnglish
Pages (from-to)p. 159-165
Number of pages7
JournalInfection, Genetics and Evolution
VolumeVol. 71
DOIs
Publication statusPublished - 1 Jul 2019

Fingerprint

tuberculosis
Portugal
Mycobacterium tuberculosis
epidemiology
population structure
public health
Epidemiology
Public Health
Epidemiologic Methods
Minisatellite Repeats
Refugees
Penetrance
Incidence
refugee
Population
Tuberculosis
drug
incidence
penetrance
minisatellite repeats

Keywords

  • Lisboa3
  • M. Tuberculosis
  • Migrants
  • MIRU-VNTR
  • RDRio
  • Spoligotyping

Cite this

Pereira, Catarina ; Gomes, Pedro ; Taveira, Ricardo ; Silva, Carla ; Maltez, Fernando ; Macedo, Rita ; Costa, Catarina ; Couvin, David ; Rastogi, Nalin ; Viveiros, Miguel ; Perdigão, João ; Portugal, Isabel. / Insights on the Mycobacterium tuberculosis population structure associated with migrants from Portuguese-speaking countries over a three-year period in Greater Lisbon, Portugal: Implications at the public health level. In: Infection, Genetics and Evolution. 2019 ; Vol. Vol. 71. pp. p. 159-165.
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Insights on the Mycobacterium tuberculosis population structure associated with migrants from Portuguese-speaking countries over a three-year period in Greater Lisbon, Portugal: Implications at the public health level. / Pereira, Catarina; Gomes, Pedro; Taveira, Ricardo; Silva, Carla; Maltez, Fernando; Macedo, Rita; Costa, Catarina; Couvin, David; Rastogi, Nalin; Viveiros, Miguel; Perdigão, João; Portugal, Isabel.

In: Infection, Genetics and Evolution, Vol. Vol. 71, 01.07.2019, p. p. 159-165.

Research output: Contribution to journalArticle

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