TY - JOUR
T1 - Insights on the genotype distribution among Cryptococcus neoformans and C. gattii portuguese clinical isolates.
AU - Maduro, A.P.
AU - Mansinho, Kamal
AU - Teles, Fernando Sérgio Rodrigues Ribeiro
AU - Silva,, I.
AU - Meyer,, W.
AU - Martins, Maria da Luz Marques
AU - Inácio, J
N1 - PMID:24077953
WOS:000329994500011
PY - 2014/2
Y1 - 2014/2
N2 - This study provides a comprehensive picture of the C. neoformans/C. gattii molecular types most often associated with human cryptococcosis in Portugal and assesses the impact of C. gattii in these infections. One hundred and twenty-two clinical isolates, from distinct patients, were identified as C. neoformans and genotyped by URA5-RFLP, with the molecular types VNI (45.5 %) and VNIII (30.9 %) being the most commonly found ones. The molecular types VNII (11.4 %) and VNIV (11.4 %) were less abundant. One patient was found to be infected with a VGII isolate. This patient exhibited unusual clinical symptoms of cryptococcosis, reinforcing the suspicion for the presence of a different genotypic pattern, as determined afterwards. This case was detected in 2007 and is the first report of a potential autochthonous C. gattii infection case in Portugal, as the patient revealed no historical record of travelling outside the country.
AB - This study provides a comprehensive picture of the C. neoformans/C. gattii molecular types most often associated with human cryptococcosis in Portugal and assesses the impact of C. gattii in these infections. One hundred and twenty-two clinical isolates, from distinct patients, were identified as C. neoformans and genotyped by URA5-RFLP, with the molecular types VNI (45.5 %) and VNIII (30.9 %) being the most commonly found ones. The molecular types VNII (11.4 %) and VNIV (11.4 %) were less abundant. One patient was found to be infected with a VGII isolate. This patient exhibited unusual clinical symptoms of cryptococcosis, reinforcing the suspicion for the presence of a different genotypic pattern, as determined afterwards. This case was detected in 2007 and is the first report of a potential autochthonous C. gattii infection case in Portugal, as the patient revealed no historical record of travelling outside the country.
U2 - 10.1007/s00284-013-0452-0
DO - 10.1007/s00284-013-0452-0
M3 - Article
C2 - 24077953
SN - 0343-8651
VL - 68
SP - 199
EP - 203
JO - Current Microbiology
JF - Current Microbiology
IS - 2
ER -