Innovation in structures and construction materials demands a more accurate performance analysis during the life cycle. In addition, climatic changes pose new challenges to civil infrastructures that were not so relevant in the past. In most cases, the traditional test methods cannot accurately assess the complex phenomena involved in durability. The modern and complex factors require a different approach to durability analysis. The purpose of this chapter is to present innovative durability tests on construction materials: wood; rammed earth, cob and unfired blocks; natural stone; bituminous binders and mixtures; and Fibre Reinforced Polymers (FRP) to concrete bonded connections. Most of these tests concern the accelerated simulation of the main phenomena involved in durability performance – ageing – of the materials and structures, such as wet-dry cycles, UV exposure, salt water immersion, salt fog cycles, and action of biological agents The demonstration and validation of the new durability test methods on construction materials are supported by the description of some case studies based on experimental research.