TY - JOUR
T1 - InMS
T2 - Chronic insomnia disorder in multiple sclerosis - A Portuguese multicentre study on prevalence, subtypes, associated factors and impact on quality of life
AU - Viana, Pedro
AU - Rodrigues, Elisabete
AU - Fernandes, Carina
AU - Matas, Andreia
AU - Barreto, Rui
AU - Mendonça, Marcelo
AU - Peralta, Rita
AU - Geraldes, Ruth
N1 - Funding Information:
The inMS study was performed as part of the programme “Esclerose Múltipla para Internos de Neurologia” (EMIN), a portuguese educational programme for young neurologists, sponsored by Biogen Idec R (Grant no. RF-POR-0197 ). However, the study did not receive any direct funding for its conduction. The authors would like to acknowledge the collaboration of the Neurology Departments' staff in each centre. Special mention to João de Sá, João Ferreira, Ana Sofia Correia, Miguel Grunho, Irene Mendes, João Paulo Gabriel, Carlos Veira, Armando Morganho, José Vale and Maria José Sá. We would like to thank Dr. Frances Chung (and University Health Network) for the licence of the STOP-BANG questionnaire ( www.stopbang.ca ); and Prof. Christopher Earley for authorisation for use of the Hopkins Telephone Diagnostic Interview questionnaire. Finally, we wish to express our gratitude to Eurotrials-Scientific Consultants for their regular support in this project, particularly in the design, implementation, data analysis and interpretation of results.
Publisher Copyright:
© 2015 Elsevier B.V. All rights reserved.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Background: Sleep may be disrupted in Multiple Sclerosis (MS), but the prevalence of chronic insomnia disorder (CID) using standard diagnostic criteria is unknown. Objectives: To determine the prevalence of CID in an MS population, the frequency of CID subtypes, associated factors and impact on quality of life (QoL). Methods: Multicentre, hospital-based cross-sectional study. An adapted version of the Brief Insomnia Questionnaire was applied to a consecutively recruited MS population. The influence of demographic, MS-related features, fatigue, medical and psychiatric comorbidities, nocturnal symptoms, other sleep disorders, dysfunctional beliefs about sleep in CID was evaluated. The relation between CID and QoL was analysed. Results: Of 206 MS patients, 22.3% fulfilled criteria for CID, with initial insomnia in 11.7%, maintenance insomnia in 11.2% and terminal insomnia in 10.2% of patients. CID was more frequent in female patients, those with nocturnal symptoms, medical comorbidities, higher levels of anxiety, depression and fatigue. Multivariable analysis identified female sex, medical comorbidities, anxiety and fatigue as independent factors for CID. CID patients had a significantly lower self-reported QoL. Conclusions: CID is prevalent in MS patients and associated with psychiatric and medical comorbidities, as well as fatigue. It has a negative impact on QoL.
AB - Background: Sleep may be disrupted in Multiple Sclerosis (MS), but the prevalence of chronic insomnia disorder (CID) using standard diagnostic criteria is unknown. Objectives: To determine the prevalence of CID in an MS population, the frequency of CID subtypes, associated factors and impact on quality of life (QoL). Methods: Multicentre, hospital-based cross-sectional study. An adapted version of the Brief Insomnia Questionnaire was applied to a consecutively recruited MS population. The influence of demographic, MS-related features, fatigue, medical and psychiatric comorbidities, nocturnal symptoms, other sleep disorders, dysfunctional beliefs about sleep in CID was evaluated. The relation between CID and QoL was analysed. Results: Of 206 MS patients, 22.3% fulfilled criteria for CID, with initial insomnia in 11.7%, maintenance insomnia in 11.2% and terminal insomnia in 10.2% of patients. CID was more frequent in female patients, those with nocturnal symptoms, medical comorbidities, higher levels of anxiety, depression and fatigue. Multivariable analysis identified female sex, medical comorbidities, anxiety and fatigue as independent factors for CID. CID patients had a significantly lower self-reported QoL. Conclusions: CID is prevalent in MS patients and associated with psychiatric and medical comorbidities, as well as fatigue. It has a negative impact on QoL.
KW - Associated factors
KW - Fatigue
KW - Insomnia
KW - Multiple sclerosis
KW - Prevalence
KW - Quality of life
UR - http://www.scopus.com/inward/record.url?scp=84941650807&partnerID=8YFLogxK
U2 - 10.1016/j.msard.2015.07.010
DO - 10.1016/j.msard.2015.07.010
M3 - Article
C2 - 26346798
AN - SCOPUS:84941650807
SN - 2211-0348
VL - 4
SP - 477
EP - 483
JO - Multiple Sclerosis and Related Disorders
JF - Multiple Sclerosis and Related Disorders
IS - 5
ER -