Injectable hydrogels based on pluronic/water systems filled with alginate microparticles for biomedical applications

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Abstract

A (model) composite system for drug delivery was developed based on a thermoresponsive hydrogel loaded with microparticles. We used Pluronic F127 hydrogel as the continuous phase and alginate microparticles as the dispersed phase of this composite system. It is well known that Pluronic F127 forms a gel when added to water in an appropriate concentration and in a certain temperature range. Pluronic F127 hydrogel may be loaded with drug and injected, in its sol state, to act as a drug delivery system in physiological environment. A rheological characterization allowed the most appropriate concentration of Pluronic F127 (15.5 wt%) and appropriate alginate microparticles contents (5 and 10 wt%) to be determined. Methylene blue (MB) was used as model drug to perform drug release studies in MB loaded Pluronic hydrogel and in MB loaded alginate microparticles/Pluronic hydrogel composite system. The latter showed a significantly slower MB release than the former (10 times), suggesting its potential in the development of dual cargo release systems either for drug delivery or tissue engineering.

Original languageEnglish
Article number1083
JournalMaterials
Volume12
Issue number7
DOIs
Publication statusPublished - 1 Jan 2019

Fingerprint

UCON 50-HB-5100
Poloxamer
Hydrogels
Alginate
Hydrogel
Methylene Blue
Water
Large scale systems
Drug delivery
Pharmaceutical Preparations
Sols
Tissue engineering
Polymethyl Methacrylate
Gels
alginic acid

Keywords

  • Alginate microparticles
  • Composites
  • Dual cargo delivery systems
  • Injectable gels
  • Pluronic/water systems
  • Rheology

Cite this

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title = "Injectable hydrogels based on pluronic/water systems filled with alginate microparticles for biomedical applications",
abstract = "A (model) composite system for drug delivery was developed based on a thermoresponsive hydrogel loaded with microparticles. We used Pluronic F127 hydrogel as the continuous phase and alginate microparticles as the dispersed phase of this composite system. It is well known that Pluronic F127 forms a gel when added to water in an appropriate concentration and in a certain temperature range. Pluronic F127 hydrogel may be loaded with drug and injected, in its sol state, to act as a drug delivery system in physiological environment. A rheological characterization allowed the most appropriate concentration of Pluronic F127 (15.5 wt{\%}) and appropriate alginate microparticles contents (5 and 10 wt{\%}) to be determined. Methylene blue (MB) was used as model drug to perform drug release studies in MB loaded Pluronic hydrogel and in MB loaded alginate microparticles/Pluronic hydrogel composite system. The latter showed a significantly slower MB release than the former (10 times), suggesting its potential in the development of dual cargo release systems either for drug delivery or tissue engineering.",
keywords = "Alginate microparticles, Composites, Dual cargo delivery systems, Injectable gels, Pluronic/water systems, Rheology",
author = "Cidade, {M. T.} and Ramos, {D. J.} and H. Carrelo and N. Calero and Borges, {J. P.}",
note = "The financial support received from the Portuguese Foundation for Science and Technology through the strategic project 288 UID/CTM/50025/2019 (Cenimat/I3N) and from the Spanish Ministerio de Economia y Competitividad as well as from V Plan Propio Universidad de Sevilla, and the European Commission (FEDER Programme) is kindly acknowledged.",
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AU - Cidade, M. T.

AU - Ramos, D. J.

AU - Carrelo, H.

AU - Calero, N.

AU - Borges, J. P.

N1 - The financial support received from the Portuguese Foundation for Science and Technology through the strategic project 288 UID/CTM/50025/2019 (Cenimat/I3N) and from the Spanish Ministerio de Economia y Competitividad as well as from V Plan Propio Universidad de Sevilla, and the European Commission (FEDER Programme) is kindly acknowledged.

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Y1 - 2019/1/1

N2 - A (model) composite system for drug delivery was developed based on a thermoresponsive hydrogel loaded with microparticles. We used Pluronic F127 hydrogel as the continuous phase and alginate microparticles as the dispersed phase of this composite system. It is well known that Pluronic F127 forms a gel when added to water in an appropriate concentration and in a certain temperature range. Pluronic F127 hydrogel may be loaded with drug and injected, in its sol state, to act as a drug delivery system in physiological environment. A rheological characterization allowed the most appropriate concentration of Pluronic F127 (15.5 wt%) and appropriate alginate microparticles contents (5 and 10 wt%) to be determined. Methylene blue (MB) was used as model drug to perform drug release studies in MB loaded Pluronic hydrogel and in MB loaded alginate microparticles/Pluronic hydrogel composite system. The latter showed a significantly slower MB release than the former (10 times), suggesting its potential in the development of dual cargo release systems either for drug delivery or tissue engineering.

AB - A (model) composite system for drug delivery was developed based on a thermoresponsive hydrogel loaded with microparticles. We used Pluronic F127 hydrogel as the continuous phase and alginate microparticles as the dispersed phase of this composite system. It is well known that Pluronic F127 forms a gel when added to water in an appropriate concentration and in a certain temperature range. Pluronic F127 hydrogel may be loaded with drug and injected, in its sol state, to act as a drug delivery system in physiological environment. A rheological characterization allowed the most appropriate concentration of Pluronic F127 (15.5 wt%) and appropriate alginate microparticles contents (5 and 10 wt%) to be determined. Methylene blue (MB) was used as model drug to perform drug release studies in MB loaded Pluronic hydrogel and in MB loaded alginate microparticles/Pluronic hydrogel composite system. The latter showed a significantly slower MB release than the former (10 times), suggesting its potential in the development of dual cargo release systems either for drug delivery or tissue engineering.

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