Inhibitors of bacterial efflux pumps that also inhibit efflux pumps of cancer cells.

Leonard Amaral, Gabriella Spengler, Ana Martins, Ana Maria Armada, J, Handzlik, K Kiec-Kononowicz, J. Molnar

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Bacteria and cancer cells frequently increase their resistance to chemotherapeutics as a consequence of therapy. Whenever studied, refractory response to chemotherapy is due to the over-expression of efflux pumps that render the bacterium or cancer cell resistant not only to the agent used for therapy, but to many, if not all other agents as well. Control over the efflux pump that bestows multidrug resistance has been a goal of research during the past decade. As a consequence of this search for inhibitors of efflux pumps, it has been noted that many agents which affect the efflux pump system of bacteria also have similar activity against efflux pumps of drug-resistant cancer cells. This review aims to identify such agents.
Original languageEnglish
Pages (from-to)2947-2957
JournalAnticancer Research
Volume32
Issue number7
Publication statusPublished - 1 Jan 2012

UN Sustainable Development Goals (SDGs)

  • SDG 3 - Good Health and Well-Being

Fingerprint Dive into the research topics of 'Inhibitors of bacterial efflux pumps that also inhibit efflux pumps of cancer cells.'. Together they form a unique fingerprint.

  • Cite this