Influence of the timing of low-dose aspirin on tolerability of prolonged-release nicotinic acid in patients at elevated cardiovascular risk

J. Delgado Alves, E. Steinhagen-Thiessen, R. Darioli, Ulrike Hostalek, A. Vogt

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objectives: To investigate the effect of low-dose aspirin administered in the morning or evening on the rate of discontinuation of prolonged-release nicotinic acid (Niaspan*) due to flushing in patients at elevated cardiovascular risk. Research design and methods: This was an observational, non-interventional study in patients at elevated cardiovascular risk due to cardiovascular disease or type 2 diabetes. Patients received prolonged-release nicotinic acid and aspirin under the usual care of their physician for 15 weeks. Main outcome measures: The main outcome measure was the rate of treatment discontinuation for flushing. Other adverse drug reactions (ADRs) were also recorded. Lipid parameters were also measured. Results: The patient population included 539 subjects (70% male); 36% had type 2 diabetes, 80% had prior cardiovascular disease, and 37% had a family history of cardiovascular disease. The rate of treatment discontinuation due to flushing did not differ (p=0.3375) between the morning aspirin group (10.6%) and the evening aspirin group (13.8%). The overall incidence of flushing was 57%. Most flushes were of mild or moderate severity and decreases occurred over time in both frequency and intensity. ADRs unrelated to flushing occurred in 6.6% of the morning aspirin group and 7.4% of the evening aspirin group. HDL-cholesterol increased by +21.3% in the overall population, together with moderate improvements in other lipid parameters. Conclusions: Flushing was the most common ADR with prolonged-release nicotinic acid treatment, as expected. The timing of aspirin administration did not influence the rate of treatment discontinuations for flushing. Marked increases in HDL-cholesterol were observed.

Original languageEnglish
Pages (from-to)2815-2820
Number of pages6
JournalCurrent Medical Research and Opinion
Volume24
Issue number10
DOIs
Publication statusPublished - Oct 2008

Keywords

  • Cardiovascular risk
  • HLD-cholesterol
  • Lipid profiles
  • Prolonged-release nicotinic acid
  • Tolerability

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