Inflammatory Myofibroblastic Tumour of the Common Bile Duct

Matilde Almeida E Sousa, Ana Carvalho, Raquel Mega, Tiago Bilhim

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Inflammatory myofibroblastic tumour is a rare entity of indeterminate biological potential with a reduced tendency for recurrence and metastasis. Although it can arise from multiple organs, the bile duct is a very rare site of origin. We report the case of a 75-year-old asymptomatic male with elevated gamma-glutamyl transferase [1575 U/L (12 - 64 U/L)] and alkaline phosphatase [271 U/L (40 - 150 U/L)]. Computed tomography showed a 17 mm hypervascular lesion in the confluence of the right and left hepatic ducts, with bile duct ectasia and right liver lobe atrophy. The patient was initially managed as having a Klatskin tumour and underwent right hepatectomy. Histology showed a spindle cell proliferation with an inflammatory infiltrate of lymphocytes, plasma cells and collagen-rich stroma, consistent with an inflammatory myofibroblastic tumour. He was discharged 30 days after admission, and nine months later remains asymptomatic. His liver function tests have normalized and follow-up tests are unremarkable.

Original languageEnglish
Pages (from-to)765-769
JournalActa Médica Portuguesa
Issue number10
Early online date7 Feb 2022
Publication statusPublished - Oct 2022


  • Bile Duct Neoplasms
  • Hepatectomy
  • Hepatic Duct
  • Common
  • Klatskin Tumour
  • Liver Function Tests


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