Infection of human keratinocytes by Streptococcus dysgalactiae subspecies dysgalactiae isolated from milk of the bovine udder

Catarina Roma-Rodrigues, Cynthia Alves-Barroco, Luis R. Raposo, Mafalda N. Costa, Elvira Fortunato, Pedro Miguel Ribeiro Viana Baptista, Maria Alexandra Núncio de Carvalho Ramos Fernandes, Ilda Santos-Sanches

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9 Citations (Scopus)


Streptococcus dysgalactiae subsp. dysgalactiae (SDSD) are considered exclusive animal pathogens; however, a putative zoonotic upper limb cellulitis, a prosthetic joint infection and an infective endocarditis were described in humans. To unravel if bovine SDSD isolates are able to infect human cells, the adherence and internalization to human primary keratinocytes of two bovine SDSD strains isolated from milk collected from udder were analyzed. Bacterial adhesion assays and confocal microscopy indicate a high adherence and internalization of SDSD isolates to human cells, suggesting for the first time the ability of bovine isolates to infect human cells. (C) 2015 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

Original languageEnglish
Pages (from-to)290-293
Number of pages4
JournalMicrobes And Infection
Issue number4
Publication statusPublished - 1 Apr 2016


  • Adhesion
  • Bovine
  • Host
  • Human keratinocytes
  • Internalization
  • Streptococcus dysgalactiae subspecies dysgalactiae

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