TY - JOUR
T1 - Increased levels of sister chromatid exchanges in military aircraft pilots
AU - Silva, Maria J.
AU - Carothers, Andrew
AU - Castelo Branco, Nuno
AU - Dias, Anabela
AU - Boavida, Maria G.
PY - 1999/4/26
Y1 - 1999/4/26
N2 - Sister chromatid exchanges (SCEs) were scored in lymphocytes of nine high-performance pilots of alphajet aircrafts and of ten control individuals from the same air base. Statistical analysis of the mean SCE count per cell in the total number of cells analyzed as well as in those having 12 or more SCEs (high-frequency cells, HFCs) revealed a significant difference between pilots and controls, after adjusting for the effect of smoking. Analysis of the cell cycle kinetic data (replication and mitotic indices) revealed no significant differences either between pilots and controls or between smokers and nonsmokers. Previously, we reported an increase in the SCE levels in workers of the aeronautical industry exposed to noise and whole-body vibration. The present results corroborate those findings and indicate that noise and whole-body vibration may cause genotoxic effects in man. Copyright (C) 1999 Elsevier Science B.V.
AB - Sister chromatid exchanges (SCEs) were scored in lymphocytes of nine high-performance pilots of alphajet aircrafts and of ten control individuals from the same air base. Statistical analysis of the mean SCE count per cell in the total number of cells analyzed as well as in those having 12 or more SCEs (high-frequency cells, HFCs) revealed a significant difference between pilots and controls, after adjusting for the effect of smoking. Analysis of the cell cycle kinetic data (replication and mitotic indices) revealed no significant differences either between pilots and controls or between smokers and nonsmokers. Previously, we reported an increase in the SCE levels in workers of the aeronautical industry exposed to noise and whole-body vibration. The present results corroborate those findings and indicate that noise and whole-body vibration may cause genotoxic effects in man. Copyright (C) 1999 Elsevier Science B.V.
KW - Aircraft pilot
KW - Noise
KW - Occupational exposure
KW - Sister chromatid exchange
KW - Vibration
UR - http://www.scopus.com/inward/record.url?scp=0032932049&partnerID=8YFLogxK
U2 - 10.1016/S1383-5718(99)00044-3
DO - 10.1016/S1383-5718(99)00044-3
M3 - Article
C2 - 10224329
AN - SCOPUS:0032932049
SN - 1383-5718
VL - 441
SP - 129
EP - 134
JO - Mutation Research - Genetic Toxicology and Environmental Mutagenesis
JF - Mutation Research - Genetic Toxicology and Environmental Mutagenesis
IS - 1
ER -