TY - JOUR
T1 - In vitro susceptibility of Leishmania infantum to artemisinin derivatives and selected trioxolanes
AU - Cortes, Sofia
AU - Albuquerque, Andreia
AU - Cabral, Lília I L
AU - Lopes, Liliana
AU - Campino, Lenea
AU - Cristiano, Maria L S
N1 - PMID: 26014947
WOS:000362952000090
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Leishmaniasis is among the world's most neglected diseases. Currently available drugs for treatment present drawbacks, urging the need for more effective, safer, and cheaper drugs. A small library of artemisinin-derived trioxanes and synthetic trioxolanes was tested against promastigote and intramacrophage amastigote forms of Leishmania infantum. The trioxolanes LC50 and LC95 presented the best activity and safety profiles, showing potential for further studies in the context of leishmanial therapy. Our results indicate that the compounds tested exhibit peroxide-dependent activity.
AB - Leishmaniasis is among the world's most neglected diseases. Currently available drugs for treatment present drawbacks, urging the need for more effective, safer, and cheaper drugs. A small library of artemisinin-derived trioxanes and synthetic trioxolanes was tested against promastigote and intramacrophage amastigote forms of Leishmania infantum. The trioxolanes LC50 and LC95 presented the best activity and safety profiles, showing potential for further studies in the context of leishmanial therapy. Our results indicate that the compounds tested exhibit peroxide-dependent activity.
UR - http://www.scopus.com/inward/record.url?scp=84940196134&partnerID=8YFLogxK
U2 - 10.1128/AAC.00298-15
DO - 10.1128/AAC.00298-15
M3 - Article
C2 - 26014947
AN - SCOPUS:84940196134
SN - 0066-4804
VL - 59
SP - 5032
EP - 5035
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 8
ER -
