In vitro susceptibility of Leishmania infantum to artemisinin derivatives and selected trioxolanes

Sofia Cortes, Andreia Albuquerque, Lília I L Cabral, Liliana Lopes, Lenea Campino, Maria L S Cristiano

Research output: Contribution to journalArticle

16 Citations (Scopus)
5 Downloads (Pure)

Abstract

Leishmaniasis is among the world's most neglected diseases. Currently available drugs for treatment present drawbacks, urging the need for more effective, safer, and cheaper drugs. A small library of artemisinin-derived trioxanes and synthetic trioxolanes was tested against promastigote and intramacrophage amastigote forms of Leishmania infantum. The trioxolanes LC50 and LC95 presented the best activity and safety profiles, showing potential for further studies in the context of leishmanial therapy. Our results indicate that the compounds tested exhibit peroxide-dependent activity.

Original languageEnglish
Pages (from-to)5032-5035
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume59
Issue number8
DOIs
Publication statusPublished - 1 Aug 2015

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