In Vitro Characterization of Doped Bioglass 45S5/HAp Coatings Obtained by CoBlastTM Deposition

Ana Sofia Pádua, Sílvia Rodrigues Gavinho, Tânia Vieira, Imen Hammami, Jorge Carvalho Silva, João Paulo Borges, Manuel Pedro Fernandes Graça

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)
43 Downloads (Pure)

Abstract

Bone replacement is one of the major medical procedures in the oral surgery field due to the progressive ageing population and to illness or trauma in younger age groups. The use of implants without biological activity and effective osseointegration increases the chances of implant failure. This work aims to improve the interaction between implants and bone by using Bioglass 45S5 (BG)/hydroxyapatite (HAp) mixtures, including copper-, zinc-, and cerium-doped BG, as well as co-doping by the mentioned metals, as coatings produced by the CoBlastTM technique. All coatings present a uniform coverage of the Ti-6Al-4V substrate. Furthermore, in vitro testing using human osteosarcoma Saos-2 cells indicated that BG/HAp coatings have no cytotoxic effect, and the used of doping agents did not alter cell adhesion, proliferation, or alkaline phosphatase (ALP) expression when compared to undoped coating. These results demonstrate that BG/HAp by CoBlastTM can be a solution to improve implants’ osseointegration.
Original languageEnglish
Article number1775
Number of pages13
JournalCOATINGS
Volume13
Issue number10
DOIs
Publication statusPublished - 16 Oct 2023

Keywords

  • Bioglass 45S5
  • cerium
  • CoBlast
  • copper
  • hydroxyapatite
  • implant coating
  • zinc

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