In Vitro and Ex Vivo Models – The Tumor Microenvironment in a Flask

Catarina Pinto, Marta Falcão Estrada, Catarina Brito

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

3 Citations (Scopus)


Experimental tumor modeling has long supported the discovery of fundamental mechanisms of tumorigenesis and tumor progression, as well as provided platforms for the development of novel therapies. Still, the attrition rates observed today in clinical translation could be, in part, mitigated by more accurate recapitulation of environmental cues in research and preclinical models. The increasing understanding of the decisive role that tumor microenvironmental cues play in the outcome of drug response urges its integration in preclinical tumor models. In this chapter we review recent developments concerning in vitro and ex vivo approaches.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
Number of pages13
Publication statusPublished - 2020

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


  • 3D cell cultures
  • Cancer models
  • Experimental tumor modeling
  • Tumor explants
  • Tumor microenvironment


Dive into the research topics of 'In Vitro and Ex Vivo Models – The Tumor Microenvironment in a Flask'. Together they form a unique fingerprint.

Cite this