TY - JOUR
T1 - Impulse control disorders in Parkinson's disease: Crossroads between neurology, psychiatry and neuroscience
AU - Bugalho, Paulo
AU - Oliveira-Maia, Albino
PY - 2013
Y1 - 2013
N2 - Non-motor symptoms contribute significantly to Parkinson's disease (PD) related disability. Impulse control disorders (ICDs) have been recently added to the behavioural spectrum of PD-related non-motor symptoms. Such behaviours are characterized by an inappropriate drive to conduct repetitive behaviours that are usually socially inadequate or result in harmful consequences. Parkinson disease impulse control disorders (PD-ICDs) have raised significant interest in the scientific and medical community, not only because of their incapacitating nature, but also because they may represent a valid model of ICDs beyond PD and a means to study the physiology of drive, impulse control and compulsive actions in the normal brain. In this review, we discuss some unresolved issues regarding PD-ICDs, including the association with psychiatric co-morbidities such as obsessive-compulsive disorder and with dopamine related side effects, such as hallucinations and dyskinesias; the relationship with executive cognitive dysfunction; and the neural underpinnings of ICDs in PD. We also discuss the contribution of neuroscience studies based on animal-models towards a mechanistic explanation of the development of PD-ICDs, specifically regarding corticostriatal control of goal directed and habitual actions.
AB - Non-motor symptoms contribute significantly to Parkinson's disease (PD) related disability. Impulse control disorders (ICDs) have been recently added to the behavioural spectrum of PD-related non-motor symptoms. Such behaviours are characterized by an inappropriate drive to conduct repetitive behaviours that are usually socially inadequate or result in harmful consequences. Parkinson disease impulse control disorders (PD-ICDs) have raised significant interest in the scientific and medical community, not only because of their incapacitating nature, but also because they may represent a valid model of ICDs beyond PD and a means to study the physiology of drive, impulse control and compulsive actions in the normal brain. In this review, we discuss some unresolved issues regarding PD-ICDs, including the association with psychiatric co-morbidities such as obsessive-compulsive disorder and with dopamine related side effects, such as hallucinations and dyskinesias; the relationship with executive cognitive dysfunction; and the neural underpinnings of ICDs in PD. We also discuss the contribution of neuroscience studies based on animal-models towards a mechanistic explanation of the development of PD-ICDs, specifically regarding corticostriatal control of goal directed and habitual actions.
KW - impulse control disorders
KW - Parkinson's disease
KW - RECEPTOR ANTAGONISTS
KW - DOPAMINE TRANSPORTER GENE
KW - RIGHT PREFRONTAL CORTEX
KW - DORSOLATERAL STRIATUM
KW - REINFORCER DEVALUATION
KW - non-motor symptoms
KW - dopamine
KW - OBSESSIVE-COMPULSIVE DISORDER
KW - DECISION-MAKING
KW - RISK-TAKING BEHAVIOR
KW - frontostriatal circuits
KW - DIRECT-CURRENT STIMULATION
KW - DORSOMEDIAL STRIATUM
U2 - 10.3233/BEN-129019
DO - 10.3233/BEN-129019
M3 - Review article
C2 - 23242359
SN - 0953-4180
VL - 27
SP - 547
EP - 557
JO - Behavioural Neurology
JF - Behavioural Neurology
IS - 4
ER -