Abstract

CO-releasing molecules (CORMs) have been widely studied for their anti-inflammatory, antiapoptotic, and antiproliferative effects. CORM-3 is a water-soluble Ru-based metal carbonyl complex, which metallates serum proteins and readily releases CO in biological media. In this work, we evaluated the anti-inflammatory and wound-healing effects of gold nanoparticles-CORM-3 conjugates, AuNPs@PEG@BSA·Ru(CO)x, exploring its use as an efficient CO carrier. Our results suggest that the nanoformulation was capable of inducing a more pronounced cell effect, at the anti-inflammatory level and a faster tissue repair, probably derived from a rapid cell uptake of the nanoformulation that results in the increase of CO inside the cell.

Original languageEnglish
Pages (from-to)1090-1101
Number of pages12
JournalACS Biomaterials Science and Engineering
Volume6
Issue number2
DOIs
Publication statusPublished - 10 Feb 2020

Keywords

  • anti-inflammatory effects
  • bovine serum albumin
  • CO-releasing molecules
  • CORM-3
  • gold nanoparticles
  • tissue regeneration

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