Improving the Anti-inflammatory Response via Gold Nanoparticle Vectorization of CO-Releasing Molecules

Alexandra R. Fernandes; Inês Mendonça-Martins; Marino F. A. Santos; Luís R. Raposo; Rita Mendes; Joana Marques; Carlos C. Romão; Maria João Romão; Teresa Santos-Silva; Pedro V. Baptista

doi:10.1021/acsbiomaterials.9b01936

Improving the Anti-inflammatory Response via Gold Nanoparticle Vectorization of CO-Releasing Molecules

Alexandra R. Fernandes, Inês Mendonça-Martins, Marino F. A. Santos, Luís R. Raposo, Rita Mendes, Joana Marques, Carlos C. Romão, Maria João Romão, Teresa Santos-Silva, Pedro V. Baptista

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

CO-releasing molecules (CORMs) have been widely studied for their anti-inflammatory, antiapoptotic, and antiproliferative effects. CORM-3 is a water-soluble Ru-based metal carbonyl complex, which metallates serum proteins and readily releases CO in biological media. In this work, we evaluated the anti-inflammatory and wound-healing effects of gold nanoparticles-CORM-3 conjugates, AuNPs@PEG@BSA·Ru(CO)_x, exploring its use as an efficient CO carrier. Our results suggest that the nanoformulation was capable of inducing a more pronounced cell effect, at the anti-inflammatory level and a faster tissue repair, probably derived from a rapid cell uptake of the nanoformulation that results in the increase of CO inside the cell.

Original language	English
Pages (from-to)	1090-1101
Number of pages	12
Journal	ACS Biomaterials Science and Engineering
Volume	6
Issue number	2
DOIs	https://doi.org/10.1021/acsbiomaterials.9b01936
Publication status	Published - 10 Feb 2020

Keywords

anti-inflammatory effects
bovine serum albumin
CO-releasing molecules
CORM-3
gold nanoparticles
tissue regeneration

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10.1021/acsbiomaterials.9b01936

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Fernandes, A. R., Mendonça-Martins, I., Santos, M. F. A., Raposo, L. R., Mendes, R., Marques, J., Romão, C. C., Romão, M. J., Santos-Silva, T., & Baptista, P. V. (2020). Improving the Anti-inflammatory Response via Gold Nanoparticle Vectorization of CO-Releasing Molecules. ACS Biomaterials Science and Engineering, 6(2), 1090-1101. https://doi.org/10.1021/acsbiomaterials.9b01936

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abstract = "CO-releasing molecules (CORMs) have been widely studied for their anti-inflammatory, antiapoptotic, and antiproliferative effects. CORM-3 is a water-soluble Ru-based metal carbonyl complex, which metallates serum proteins and readily releases CO in biological media. In this work, we evaluated the anti-inflammatory and wound-healing effects of gold nanoparticles-CORM-3 conjugates, AuNPs@PEG@BSA·Ru(CO)x, exploring its use as an efficient CO carrier. Our results suggest that the nanoformulation was capable of inducing a more pronounced cell effect, at the anti-inflammatory level and a faster tissue repair, probably derived from a rapid cell uptake of the nanoformulation that results in the increase of CO inside the cell.",

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Fernandes, AR , Mendonça-Martins, I , Santos, MFA , Raposo, LR , Mendes, R, Marques, J, Romão, CC , Romão, MJ , Santos-Silva, T & Baptista, PV 2020, 'Improving the Anti-inflammatory Response via Gold Nanoparticle Vectorization of CO-Releasing Molecules', ACS Biomaterials Science and Engineering, vol. 6, no. 2, pp. 1090-1101. https://doi.org/10.1021/acsbiomaterials.9b01936

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AU - Mendonça-Martins, Inês

AU - Santos, Marino F. A.

AU - Raposo, Luís R.

AU - Mendes, Rita

AU - Marques, Joana

AU - Romão, Carlos C.

AU - Romão, Maria João

AU - Santos-Silva, Teresa

AU - Baptista, Pedro V.

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AB - CO-releasing molecules (CORMs) have been widely studied for their anti-inflammatory, antiapoptotic, and antiproliferative effects. CORM-3 is a water-soluble Ru-based metal carbonyl complex, which metallates serum proteins and readily releases CO in biological media. In this work, we evaluated the anti-inflammatory and wound-healing effects of gold nanoparticles-CORM-3 conjugates, AuNPs@PEG@BSA·Ru(CO)x, exploring its use as an efficient CO carrier. Our results suggest that the nanoformulation was capable of inducing a more pronounced cell effect, at the anti-inflammatory level and a faster tissue repair, probably derived from a rapid cell uptake of the nanoformulation that results in the increase of CO inside the cell.

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Improving the Anti-inflammatory Response via Gold Nanoparticle Vectorization of CO-Releasing Molecules

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