Improved extraction of fluoroquinolones with recyclable ionic-liquid-based aqueous biphasic systems

Hugo F D Almeida, Mara G. Freire, Isabel M. Marrucho

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

In the past few years, the improvement of advanced analytical tools allowed to confirm the presence of trace amounts of metabolized and unchanged active pharmaceutical ingredients (APIs) in wastewater treatment plants (WWTPs) as well as in freshwater surfaces. It is known that the continuous contact with APIs, even at very low concentrations (ng L-1-μg L-1), leads to serious human health problems. In this context, this work shows the feasibility of using ionic-liquid-based aqueous biphasic systems (IL-based ABS) in the extraction of quinolones present in aqueous media. In particular, ABS composed of imidazolium- and phosphonium-based ILs and aluminium-based salts (already used in water treatment plants) were evaluated in one-step extractions of six fluoroquinolones (FQs), namely ciprofloxacin, enrofloxacin, moxifloxacin, norfloxacin, ofloxacin and sarafloxacin, and extraction efficiencies up to 98% were obtained. Despite the large interest devoted to IL-based ABS as extractive systems of outstanding performance, their recyclability/reusability has seldomly been studied. An efficient extraction/cleaning process of the IL-rich phase is here proposed by FQs induced precipitation. The recycling of the IL and its further reuse without losses in the ABS extractive performance for FQs were established, as confirmed by the four consecutive removal/extraction cycles evaluated. This novel recycling strategy supports IL-based ABS as sustainable and cost-efficient extraction platforms.

Original languageEnglish
Pages (from-to)2717-2725
Number of pages9
JournalGreen Chemistry
Volume18
Issue number9
DOIs
Publication statusPublished - 2016

Fingerprint

Ionic Liquids
Fluoroquinolones
Ionic liquids
Recycling
sarafloxacin
Norfloxacin
Ofloxacin
Water Purification
Quinolones
Ciprofloxacin
Waste Water
Fresh Water
Aluminum
Pharmaceutical Preparations
Drug products
drug
recycling
Salts
Costs and Cost Analysis
Water treatment plants

Cite this

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title = "Improved extraction of fluoroquinolones with recyclable ionic-liquid-based aqueous biphasic systems",
abstract = "In the past few years, the improvement of advanced analytical tools allowed to confirm the presence of trace amounts of metabolized and unchanged active pharmaceutical ingredients (APIs) in wastewater treatment plants (WWTPs) as well as in freshwater surfaces. It is known that the continuous contact with APIs, even at very low concentrations (ng L-1-μg L-1), leads to serious human health problems. In this context, this work shows the feasibility of using ionic-liquid-based aqueous biphasic systems (IL-based ABS) in the extraction of quinolones present in aqueous media. In particular, ABS composed of imidazolium- and phosphonium-based ILs and aluminium-based salts (already used in water treatment plants) were evaluated in one-step extractions of six fluoroquinolones (FQs), namely ciprofloxacin, enrofloxacin, moxifloxacin, norfloxacin, ofloxacin and sarafloxacin, and extraction efficiencies up to 98{\%} were obtained. Despite the large interest devoted to IL-based ABS as extractive systems of outstanding performance, their recyclability/reusability has seldomly been studied. An efficient extraction/cleaning process of the IL-rich phase is here proposed by FQs induced precipitation. The recycling of the IL and its further reuse without losses in the ABS extractive performance for FQs were established, as confirmed by the four consecutive removal/extraction cycles evaluated. This novel recycling strategy supports IL-based ABS as sustainable and cost-efficient extraction platforms.",
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Improved extraction of fluoroquinolones with recyclable ionic-liquid-based aqueous biphasic systems. / Almeida, Hugo F D; Freire, Mara G.; Marrucho, Isabel M.

In: Green Chemistry, Vol. 18, No. 9, 2016, p. 2717-2725.

Research output: Contribution to journalArticle

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