TY - JOUR
T1 - Important cytotoxic and cytostatic effects of new copper(i)-phosphane compounds with N,N, N,O and N,S bidentate ligands
AU - Morais, Tânia S.
AU - Jousseaume, Yann
AU - Piedade, M. Fátima M.
AU - Roma-Rodrigues, Catarina
AU - Fernandes, Alexandra R.
AU - Marques, Fernanda
AU - Villa De Brito, Maria J.
AU - Helena Garcia, M.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - A family of six phosphane Cu(i) complexes bearing N,N, N,O and N,S bidentate ligands was synthesized. All the compounds were fully characterized by classical analytical and spectroscopic methods, and five of them were also characterized by X-ray diffraction studies. All the compounds exhibit high cytotoxicity against the human breast cancer cell line MCF7 with IC50 values far lower than those found for cisplatin, a current chemotherapeutic in clinical use. Compounds 1 and 3 induce cell cycle arrest in the G2/M phase and cell death by apoptosis. The cytotoxic and cytostatic effects of these compounds on MCF7 cells suggest that they are suitable for further in vivo studies with breast cancer models.
AB - A family of six phosphane Cu(i) complexes bearing N,N, N,O and N,S bidentate ligands was synthesized. All the compounds were fully characterized by classical analytical and spectroscopic methods, and five of them were also characterized by X-ray diffraction studies. All the compounds exhibit high cytotoxicity against the human breast cancer cell line MCF7 with IC50 values far lower than those found for cisplatin, a current chemotherapeutic in clinical use. Compounds 1 and 3 induce cell cycle arrest in the G2/M phase and cell death by apoptosis. The cytotoxic and cytostatic effects of these compounds on MCF7 cells suggest that they are suitable for further in vivo studies with breast cancer models.
UR - http://www.scopus.com/inward/record.url?scp=85048401535&partnerID=8YFLogxK
U2 - 10.1039/c8dt01653d
DO - 10.1039/c8dt01653d
M3 - Article
AN - SCOPUS:85048401535
SN - 1477-9226
VL - 47
SP - 7819
EP - 7829
JO - Dalton Transactions
JF - Dalton Transactions
IS - 23
ER -
